A STUB1-CHIC2 complex inhibits CD8(+) T cells to restrain tumor immunity.
LaFleur MW, Milling LE, Prathima P, Li V, Lemmen AM, Streeter ISL, Heisig PKS, Derosia NM, Riffo E, Xu H, Nguyen TH, Kolengaden A, Markson SC, Doench JG, Sharpe AH
Nat Immunol. 2025 Sep;26(9):1476-1487. doi: 10.1038/s41590-025-02231-6. Epub 2025 Aug 12.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 238124 | pLX_305_OVA_Blasticidin | Enables expression of Ovalbumin with Blasticidin selectable marker. |
| 238125 | pRRL-SFFV_V5-CHIC2_Tomato | Expresses V5-tagged CHIC2 with Tomato selectable marker. |
| 238126 | pRRL-SFFV_V5-CHIC2_IFRPDdel_Tomato | Expresses V5-tagged CHIC2 (with IFRPD deletion) with Tomato selectable marker. |
| 238127 | pRRL-SFFV_V5-CHIC2-K117R_Tomato | Expresses V5-tagged CHIC2 (with K117R mutation) with Tomato selectable marker. |
| 238128 | pRRL-SFFV_V5-CHIC2-C6S_Tomato | Expresses V5-tagged CHIC2 (with C6S mutation) with Tomato selectable marker. |
| 238129 | pRRL-SFFV_STUB1-UBOXdel-V5_Tomato | Expresses V5-tagged STUB1 (with UBOX deletion) with Tomato selectable marker. |