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High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1

Judith Reeks, Pravin Mahajan, Mellissa Clark, Suzanna R. Cowan, Elena Di Daniel, Christopher P. Earl, Samantha Fisher, Rhian S. Holvey, Scott M. Jackson, Emyr Lloyd-Evans, Carmine M. Morgillo, Paul N. Mortenson, Marc O’Reilly, Caroline J. Richardson, Patrick Schöpf, Daniel M. Tams, Helen Waller-Evans, Simon E. Ward, Stuart Whibley, Pamela A. Williams, and Christopher N. Johnson
Structure, 2025 (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
238303pACEMam2-TRPML1Expression of human TRPML1 in mammalian cells

Antibodies from Article