High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1.
Reeks J, Mahajan P, Clark M, Cowan SR, Di Daniel E, Earl CP, Fisher S, Holvey RS, Jackson SM, Lloyd-Evans E, Morgillo CM, Mortenson PN, O'Reilly M, Richardson CJ, Schopf P, Tams DM, Waller-Evans H, Ward SE, Whibley S, Williams PA, Johnson CN
Structure. 2025 Aug 7;33(8):1374-1385.e7. doi: 10.1016/j.str.2025.05.014. Epub 2025 Jun 17.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 238303 | pACEMam2-TRPML1 | Expression of human TRPML1 in mammalian cells |