Evolved cytidine and adenine base editors with high precision and minimized off-target activity by a continuous directed evolution system in mammalian cells.
Zhao N, Zhou J, Tao T, Wang Q, Tang J, Li D, Gou S, Guan Z, Olajide JS, Lin J, Wang S, Li X, Zhou J, Gao Z, Wang G
Nat Commun. 2024 Sep 17;15(1):8140. doi: 10.1038/s41467-024-52483-3.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 226583 | pCMV-N2-BE4-puro | Express N2-BE4 base editor in mammalian cells |
| 226584 | pCMV_N7-BE4-puro | Express N7-BE4 base editor in mammalian cells |
| 226586 | Lenti-E4-ABE-Cas9n-puro | Express E4-ABE in mammalian cells |
| 226587 | Lenti-E2-ABE-Cas9n-puro | Express E2-ABE in mammalian cells |
| 226588 | Lenti-E14-ABE-Cas9n-puro | Express E14-ABE in mammalian cells |