In vivo production of an anti-HIV antibody in mice by non-viral gene knock-in in primate hematopoietic stem and progenitor cells.
Castelli JMP, Poljakov K, Jwa Y, Cunningham R, Cassidy ME, Gray MD, Sanchez Gaytan JN, Enstrom MR, Gastelum G, Wang Z, Linton JD, Rongvaux A, Taylor JJ, Adair JE
Mol Ther. 2026 Feb 2:S1525-0016(26)00081-X. doi: 10.1016/j.ymthe.2026.01.038.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 241002 | pCMVp_eGFP | For targeted gene knock-in at NHP IGH locus and constitutive expression of GFP |
| 241003 | pVH4p_eGFP | For targeted gene knock-in at NHP IGH locus and B cell-specific expression of GFP |
| 241004 | pVH4p_3BNC117_muSplice | For targeted gene knock-in at NHP IGH locus and B cell-specific expression of full-length 3BNC117 following endogenous splicing |
| 241005 | pVH4p_10-1074_muSplice | For targeted gene knock-in at NHP IGH locus and B cell-specific expression of full-length 10-1074 following endogenous splicing |
| 241007 | pTT3_10-1074_NHP_IgG | Expresses full-length 10-1074 |
| 241008 | pTT3_3BNC117_NHP_IgG | Expresses full-length 3BNC117 |