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Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology.

Xing D, Bai T, Neyisci O, Paylakhi SZ, Duval AJ, Tekin Y, Adli M
Nat Commun. 2025 Jul 18;16(1):6631. doi: 10.1038/s41467-025-61848-1. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
242189AAVS1_CAG_OsTIR1_F74G_S210AAID 2.0's higher degradation efficiency came with target-specific basal degradation and slower recovery rates. To address these limitations, we employed base-editing-mediated mutagenesis followed by s

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