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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder.

Ghoochani A, Heiby JC, Rawat ES, Medoh UN, Di Fraia D, Dong W, Gastou M, Rastogi M, Hernandez V, Nyame K, Laqtom NN, Durso W, Valkova C, Isakova A, Kaether C, Wernig M, Gomez-Ospina N, Franke C, Ori A, Abu-Remaileh M
Cell. 2026 Feb 5;189(3):765-782.e31. doi: 10.1016/j.cell.2025.12.012. Epub 2026 Jan 22. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
227951pMX-Flag-GFP_SLC45A1Co-localisation experiment
227952pMX-Flag-GFP_PLEKHB1Co-localisation experiment
227954pMX-Flag-GFP_TMEM88BCo-localisation experiment
227955pMX-Flag-GFP_TMEM256Co-localisation experiment
227958pcDNA-pDEST_TMEM192_BirA_FlagBioID experiment
227959pcDNA-pDEST_BirA_Flag_SLC45A1BioID experiment
227960pcDNA-pDEST_BirA_FlagBioID experiment
242340hCBLN3-EGFPmammalian expression construct for human cerebellin 3 precursor C-terminally tagged with EGFP
242341hEDIL3-EGFPmammalian expression construct for human EGF-like repeats and discoidin I-like domains 3 C-terminally tagged with EGFP
242342hENPP5-EGFPmammalian expression construct for human ectonucleotide pyrophosphatase/phosphodiesterase family member 5 C-terminally tagged with EGFP
242343hPDGFA-EGFPmammalian expression construct for human Platelet-derived growth factor subunit A C-terminally tagged with EGFP

Antibodies from Article