Potentiation of mitochondrial function by mitoDREADD-G(s) reverses pharmacological and neurodegenerative cognitive impairment in mice.
Pagano Zottola AC, Martin-Jimenez R, Lavanco G, Hamel-Cote G, Ramon-Duaso C, Rodrigues RS, Mariani Y, Khan M, Drago F, Jean S, Rio IB, Jimenez-Blasco D, Egana-Huguet J, Eraso-Pichot A, Beriain S, Cannich A, Vidal-Palencia L, Infantino R, Julio-Kalajzic F, Gisquet D, Goncalves A, Al-Younis I, Baussan Y, Duvezin-Caubet S, Devin A, Soria-Gomez E, Puente N, Bolanos JP, Grandes P, Pouvreau S, Busquets-Garcia A, Marsicano G, Bellocchio L, Hebert-Chatelain E
Nat Neurosci. 2025 Sep;28(9):1844-1857. doi: 10.1038/s41593-025-02032-y. Epub 2025 Aug 11.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 247957 | pcDNA5/FRT-DREADD-Gs | expresses HA-DREADD-Gs |
| 247958 | pcDNA3.1-MitoDREADD-Gs | expresses HA-MitoDREADD-Gs |
| 247959 | pAAV-DIO-DREADD-Gs | Cre dependant viral expression of HA-DREADD-Gs |
| 247960 | pAAV-DIO-MitoDREADD-Gs | Cre dependant viral expression of HA-MitoDREADD-Gs |