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Connectome-seq: High-throughput Mapping of Neuronal Connectivity at Single-Synapse Resolution via Barcode Sequencing.

Chen D, Isakova A, Wan ZJ, Wagner MJ, Wu Y, Zhao BS
bioRxiv [Preprint]. 2025 May 26:2025.02.13.638129. doi: 10.1101/2025.02.13.638129. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
247715hSyn-PreSynBar-hSyn-PreRNA shortSynBar protein and RNA construct used in HEK and neuron culture experiment.
247716hSyn-PostSynBar-hSyn-PostRNA shortSynBar protein and RNA construct used in HEK and neuron culture experiment.
247717hSyn-PreSynBar-hSyn-PreRNA barcode landing padThe set of SynBar constructs used in the optimized connectome-seq experiments
247718hSyn-Cre-hSyn-PreRNA barcode landing pad (PPIB)The set of RNA constructs used to produce barcode library in the optimized connectome-seq experiments. Also used for Basescope experiment.
247719hSyn-DIO-PostSynBar-P2A-mCherryThe set of SynBar constructs used in the optimized connectome-seq experiments.
247720hSyn-Cre-hSyn-PostRNA barcode landing pad (dapB)The set of RNA constructs used to produce barcode library in the optimized connectome-seq experiments. Also used for Basescope experiment.
247721sCAG-DIO-oScarlet3Used for AAV1 tracing experiment.

Antibodies from Article