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Jennifer Doudna Lab: Recurrent acquisition of nuclease-protease pairs in antiviral immunity

Doudna J et al.
Unpublished

Plasmids from Article

ID Plasmid Purpose
248931pTet_PflHamMABHachiman from P. fluorescens under pTet control
248933pTet_PflHamMA(S157A)BHachiman from P. fluorescens under pTet control with HamA mutated (S157A)
248934pTet_PflHamMAB(D207A)Hachiman from P. fluorescens under pTet control with HamB mutated (D207A)
248935pTet_PflHamM(I118K)ABHachiman from P. fluorescens under pTet control with HamM mutated (I118K)
248937pTet_PflHamM(I118K,I218K)ABHachiman from P. fluorescens under pTet control with HamM mutated (I118K,I218K)
248938pTet_PflHamMA(deltaA)BHachiman from P. fluorescens under pTet control with the dHamA domain removed
248939pTet_PflHamMA(S157A)(deltaA)BHachiman from P. fluorescens under pTet control with the dHamA domain removed and with a protease S157A mutation
248940pTet_PflHamMA(-cJun)BHachiman from P. fluorescens under pTet control with cJun fused to the protease domain and natural linker
248941pTet_PflHamMA(S157A)(-cJun)BHachiman from P. fluorescens under pTet control with cJun fused to the protease domain and natural linker and the protease mutated (S157A)
248942pTet_PflHamM(pre-cut)ABHachiman from P. fluorescens under pTet control with HamM programmed breaks in the peptide backbone at I118 and I218
248943exp_PflHamMHis-MBP-HamM from P. fluorescens for overexpression.
248946pLG017_Avs1a(I234K)AVAST from E. piriflorinigrans with Avs1a mutated (I234K)
248947pLG017_Avs1a(I134K,I234K)AVAST from E. piriflorinigrans with Avs1a mutated (I134K, I234K)
248948pLG017_FLAG-Avs1aAVAST from E. piriflorinigrans with an N-terminal 3xFLAG tag fused to Avs1a
248949pLG017_FLAG-Avs1a(I134K,I234K)AVAST from E. piriflorinigrans with an N-terminal 3xFLAG tag fused to Avs1a (I134K, I234K)
248950pLG017_Avs1a_chimeraAVAST from E. piriflorinigrans with Avs1a replaced with Avs1a from Citrobacter Avs1a
248952pJEX_lambdaterminasephage lambda large terminase subunit under control of a crystal violet inducible promoter
248953pTet_KaeCanABCCanABC from K. aerogenes under control of pTet and the native promoter
248954pTet_KaeCanA(C187A)BCCanABC from K. aerogenes under control of pTet and the native promoter, with CanA mutated (C187A)
248955pTet_KaeCanABC(H271A)CanABC from K. aerogenes under control of pTet and the native promoter, with CanC mutated (H271A)
248956pTet_KaeCanABC(G104K)CanABC from K. aerogenes under control of pTet and the native promoter, with CanC mutated (G104K)
248957pTet_KaeCanABC(G189K)CanABC from K. aerogenes under control of pTet and the native promoter, with CanC mutated (G189K)
248958pTet_KaeCanABC(G104K,G189K)CanABC from K. aerogenes under control of pTet and the native promoter, with ChyC mutated (G104K,G189K)
248959exp_KaeCanABHis-MBP-CanAB from K. aerogenes for overexpression.
248960exp_KaeCanCHis-MBP-CanC from K. aerogenes for overexpression.

Antibodies from Article