CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Bose RS, Travaglini KJ, Lam VL, Goodness D, Ta T, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan HS, Carroll EC, Lawrence RE, Gestwicki JE, Rexach JE, Eisenberg DS, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M
Cell. 2026 Jan 28:S0092-8674(25)01487-4. doi: 10.1016/j.cell.2025.12.038.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 250736 | pAJS1197 Cul5-3xFlag-T2A-mApple | Vector for lentiviral expression of Cul5-3x-Flag-T2A-mApple |
| 250737 | pAJS1203 GFP-3xFlag-T2A-mApple | Vector for lentiviral expression of EmGFP-3x-Flag-T2A-mApple |
| 250738 | pAJS1205 GFP-Tau-1-50-T2A-mApple | Vector for lentiviral expression of GFP-0N3R-Tau1_50-T2A-mApple |
| 250739 | pAJS1206 GFP-Tau-40-90-T2A-mApple | Vector for lentiviral expression of GFP-0N3R-Tau40-90-T2A-mApple |
| 250740 | pAJS1207 GFP-Tau-80-130-T2A-mApple | Vector for lentiviral expression of GFP-0N3R-Tau80_130-T2A-mApple |
| 250741 | pAJS1208 GFP-Tau-120-170-T2A-mApple | Vector for lentiviral expression of GFP-0N3R-Tau120_170-T2A-mApple |
| 250742 | pAJS1209 GFP-Tau-160-210-T2A-mApple | Vector for lentiviral expression of GFP-0N3R-Tau160_210-T2A-mApple |
| 250743 | pAJS1210 GFP-Tau-200-250-T2A-mApple | Vector for lentiviral expression of GFP-0N3R-Tau200_250-T2A-mApple |
| 250744 | pAJS1211 GFP-Tau-240-290-T2A-mApple | Vector for lentiviral expression of GFP-0N3R-Tau240_290-T2A-mApple |
| 250745 | pAJS1212 GFP-Tau-280-352-T2A-mApple | Vector for lentiviral expression of GFP-0N3R-Tau80_130-T2A-mApple |
| 250747 | pAJS1184 GFP-Tau-T2A-mApple | Vector for expression of emGFP-0N3R-Tau-T2A-mApple. Ratiometric reporter for 0N3R tau levels |
| 250748 | pAJS1154 GFP | Vector for lentiviral expression of GFP in iPSC-derived neurons. Control for pAJS1149 |
| 250751 | pAJS1228 His-Sumo-Tau-1-172 | Vector for bacterial expression of tau 1-172 with scarless SMNT3/Ulp1 cleavage |
| 250752 | pAJS1229 His-Sumo-Tau-1-176 | Vector for bacterial expression of tau 1-176 with scarless SMNT3/Ulp1 cleavage |
| 250753 | pAJS1200 SOCS4-3xFlag-T2A-mApple | Vector for lentiviral expression of SOCS4-3x-Flag-T2A-mApple |
| 250754 | pAJS1216 GFP-Tau-80-130-IRES-mApple | Vector for lentiviral expression of GFP-0N3R-Tau80_130-IRES-mApple |
| 250755 | pAJS1219 GFP-IRES-mApple | Vector for lentiviral expression of GFP-IRES-mApple. Used as a control with plasmids pAJS1184, pAJS1216 |
| 250756 | pAJS1222 SOCS4-HA-IRES-Puro-T2A-mTagBFP2 | Vector for lentiviral expression of SOCS4-HA with a Puro-T2A-mTAGBFP2 marker |
| 250758 | pAJS1085 pET His-Sumo-ORF | Vector for bacterial expression of proteins with scarless SMNT3/Ulp1 cleavage |