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Alexis Jourdain Lab: Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis.

Strefeler A, Baker ZN, Chollet S, Foged MM, Guerra RM, Ivanisevic J, Gallart-Ayala H, Pagliarini DJ, Jourdain AA
Nat Metab. 2025 Nov;7(11):2221-2235. doi: 10.1038/s42255-025-01419-2. Epub 2025 Nov 13. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
258045pLENTICRISPR v2 DHODH sg1Knockout
258046pLENTICRISPR v2 DHODH sg2Knockout
258047pLENTICRISPR v2 CAD sg1Knockout
258048pLENTICRISPR v2 CAD sg2Knockout
258050pLENTICRISPR v2 UMPS sg2Knockout
258051pLENTICRISPR v2 SPICE1 sg1Knockout
258053pLENTICRISPR v2 IPO5 sg1Knockout
258054pLENTICRISPR v2 IPO5 sg2Knockout
258057pLENTICRISPR v2 COQ3 sg1Knockout
258058pLENTICRISPR v2 COQ3 sg2Knockout
258059pLENTICRISPR v2 COQ5 sg1Knockout
258060pLENTICRISPR v2 COQ5 sg2Knockout
258061pLENTICRISPR v2 COQ6 sg1Knockout
258062pLENTICRISPR v2 COQ6 sg2Knockout
258063pLENTICRISPR v2 NAA30 sg1Knockout
258064pLENTICRISPR v2 NAA30 sg2Knockout
258066pLENTICRISPR v2 C19orf53 sg2Knockout
258067pLENTICRISPR v2 COQ2 sg1Knockout
258068pLENTICRISPR v2 COQ2 sg2Knockout
258070pLENTICRISPR v2 COQ7 sg2Knockout
258071pLentiCRISPR v2 PPP1R18 sg1Knockout
258075pLENTICRISPR V2 NUDT5 sg1Knockout
258076pLENTICRISPR V2 NUDT5 sg2Knockout
258078pLV-puro-NUDT5_70-74-RTLHY-AAAAA-3xFLAGOverexpression
258079pLV-puro-NUDT5-3xFLAGOverexpression
258080pLV-puro-NUDT5-E112Q-3xFLAGOverexpression

Antibodies from Article