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A Flow Cytometry-Based Assay to Quantify the Binding of Transmembrane Ligands to Their Cognate Receptors Using Fluorescent Virus-Like Particles.

Kim CM, Gaballa M, Lee D, Jouanguy E, Zhang SY, Casanova JL, Yatim A
Bio Protoc. 2026 Jul 5;16(13):e5726. doi: 10.21769/BioProtoc.5726. eCollection 2026 Jul 5. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
257941psPAX2_D64V_NC_TagBFPFor integrase-deficient, TagBFP-labeled virus-like particle production in mammalian cells
257960pCMV6_ICAM-1 WTExpresses wild-type ICAM-1 in mammalian cells
257961pCMV6_ICAM-1 E34AExpresses ICAM-1 containing the E34A mutation, abrogating binding to LFA-1, in mammalian cells

Antibodies from Article