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Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation.

Zhang X, Wong W, Cho HS, Yang D, Dixon G, Luo R, Liu D, Torre D, Umeda S, Gonzalez F, Askan G, Yavas A, Damodaran JR, Rickert RW, Kappagantula R, Pan FC, Aveson VG, Grimont A, Fall WB, Wang X, Pulecio J, Kaplan SJ, Pan H, Peng XL, Yeh JJ, Leach SD, Iacobuzio-Donahue CA, Chandwani R, Leslie CS, Huangfu D
Dev Cell. 2026 May 19:S1534-5807(26)00159-0. doi: 10.1016/j.devcel.2026.04.012. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
258166HA-L-SA-2A-PuroR-GFP-TRE-HA-RDNA template for insertion of doxycycline inducible GFP cassette into the human AAVS1 site
258167HA-L-SA-2A-PuroR-GFP-KRASG12V-TRE-HA-RDNA template for insertion of doxycycline inducible GFP-KRAS-G12V cassette into the human AAVS1 site

Antibodies from Article