Remodeling synaptic connections via engineered neuron-astrocyte interactions.
Kim SH, Won W, Kim GH, Kook YH, Son S, Choi S, Kang DY, Park MG, Choi YJ, Won SS, Shin J, Jeong Y, Lee KJ, Lee CJ, Lee S
Nat Commun. 2026 Apr 15;17(1):3490. doi: 10.1038/s41467-026-71440-w.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 259743 | pCMV-igκ-mEGFP-TM | A mammalian expression vector designed to express the mEGFP-tagged SynTrogo ligand in vitro under the control of the CMV promoter. |
| 259744 | pCMV-igκ-αGFP-TM-FusionRed | A mammalian expression vector designed to express the FusionRed-tagged SynTrogo receptor in vitro under the control of the CMV promoter. |
| 259745 | pAAV-CaMKIIα-igκ-mEGFP-TM | An AAV expression vector designed to target the SynTrogo ligand specifically to excitatory neurons in vivo under the control of the CaMKIIα promoter. |
| 259746 | pAAV-GfaABC1D-igκ-αGFP-TM-mScarlet | An AAV expression vector designed for astrocyte-specific expression of the mScarlet-tagged SynTrogo receptor in vivo, driven by the GfaABC1D promoter. |
| 259747 | pAAV-GfaABC1D-Lck-mScarlet | An AAV control vector expressing membrane-targeted mScarlet (Lck-mScarlet) specifically in astrocytes under the GfaABC1D promoter. |
| 259748 | pAAV-CaMKIIα-Synaptophysin-TagBFP | An AAV vector expressing TagBFP-synaptophysin under the CaMKIIα promoter to selectively label presynaptic vesicles in excitatory neurons in vivo. |