The human DeltaNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function.
Lin SC, Karoly ED, Taatjes DJ
Aging Cell. 2013 Oct;12(5):863-72. doi: 10.1111/acel.12108. Epub 2013 Jun 25.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 49242 | pIRES2-EGFP-p53 WT | expresses human wt p53 and EGFP in mammalian cells |
| 49243 | pIRES2-mCherry-p53 deltaN | expresses human p53 deltaN and mCherry in mammalian cells |
| 49244 | pIRES2-EGFP-deltaNp53:WTp53 | expresses human p53 deltaN linked to full length p53 with C terminal His tag and also expresses EGFP in mammalian cells |
| 49245 | pIRES2-EGFP-p53 tethered | expresses two human WT p53s tethered together and also expresses EGFP in mammalian cells |