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Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.
Solowska JM, D'Rozario M, Jean DC, Davidson MW, Marenda DR, Baas PW
J Neurosci. 2014 Jan 29;34(5):1856-67. doi: 10.1523/JNEUROSCI.3309-13.2014.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
57683tdEos-Tubulin-C-18Localization: Microtubules, Excitation: 505 / 569, Emission: 516 / 581
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89318pCMV-Tag/C448Y with 5'UTRexpression of C448Y spastin M1 and M87 in mammalian cells
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89319pCMV-Tag/M1C448Yexpression of M1 C448Y spastin in mammalian cells
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89320pCMV-Tag/M87 C448Yexpression of M87 C448Y spastin in mammalian cells
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89321pCMV-Tag/WT M1expression of M1 C448Y spastin in mammalian cells
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89322pCMV-Tag/WT M87expression of WT M87 spastin in mammalian cells
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89323pIRES RED/SP M1C448YExpression of RFP and M1C448Y spastin in mammalian cells
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89324pIRES RED/SP M87C448YExpression of RFP and M87C448Y spastin in mammalian cells
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89325pTRE/SP C448Y with 5'UTRInducible expression of C448Y spastin M1 and M87 in mammalian cells
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89326pTRE/SP M1C448YInducible expression of M1C448Y spastin in mammalian cells
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89327pTRE/SP M1WTInducible expression of WT M1 spastin in mammalian cells
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89328pTRE/SP M87 WTInducible expression of WT M87 spastin in mammalian cells
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89329pTRE/SP M87C448YInducible expression of M87 C448Y spastin in mammalian cells
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89330pTRE/WT SP with 5'UTRInducible expression of WT spastin M1 and M87 in mammalian cells
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