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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.
Pasquali L, Gaulton KJ, Rodriguez-Segui SA, Mularoni L, Miguel-Escalada I, Akerman I, Tena JJ, Moran I, Gomez-Marin C, van de Bunt M, Ponsa-Cobas J, Castro N, Nammo T, Cebola I, Garcia-Hurtado J, Maestro MA, Pattou F, Piemonti L, Berney T, Gloyn AL, Ravassard P, Gomez-Skarmeta JL, Muller F, McCarthy MI, Ferrer J
Nat Genet. 2014 Feb;46(2):136-43. doi: 10.1038/ng.2870. Epub 2014 Jan 12. PubMed Article

Plasmids from Article

ID Plasmid Purpose
60249pENTR D-TOPO-C2_8This plasmid contains a human pancreatic islet inactive enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60250pENTR D-TOPO-C2_10This plasmid contains a human pancreatic islet inactive enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60251pENTR D-TOPO-C2_11This plasmid contains a human pancreatic islet inactive enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60252pENTR D-TOPO-C2_13This plasmid contains a human pancreatic islet inactive enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60253pENTR D-TOPO-C2_14This plasmid contains a human pancreatic islet inactive enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60254pENTR D-TOPO-C3_5This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60255pENTR D-TOPO-C3_6This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60256pENTR D-TOPO-C3_7This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60257pENTR D-TOPO-C3_8This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60258pENTR D-TOPO-C3_9This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60259pENTR D-TOPO-C3_10This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60260pENTR D-TOPO-C3_11This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60261pENTR D-TOPO-C3_13This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60262pENTR D-TOPO-C3_15This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60263pENTR D-TOPO-C3_17This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60264pENTR D-TOPO-C3_18This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60265pENTR D-TOPO-C3_19This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60266pENTR D-TOPO-C3_20This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60267pENTR D-TOPO-C3_22This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60268pENTR D-TOPO-C3_25This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60269pENTR D-TOPO-C3_26This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60270pENTR D-TOPO-C3_27This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60271pENTR D-TOPO-C3_28This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60272pENTR D-TOPO-C3_29This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60273pENTR D-TOPO-C3_31This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60274pENTR D-TOPO-C3_32This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60275pENTR D-TOPO-C3_33This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60276pENTR D-TOPO-C3_34This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60277pENTR D-TOPO-C3_36This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60278pENTR D-TOPO-C3_37This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60279pENTR D-TOPO-C3_38This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60280pENTR D-TOPO-C3_39This plasmid contains a human pancreatic islet active enhancer, which can be shuttled into a Gateway destination vector, such as pGL4.23-Gateway.
60286pGL4.23 C2_8This plasmid contains a human pancreatic islet inactive enhancer, a minimal promoter and a luc2 gene.
60287pGL4.23 C2_10This plasmid contains a human pancreatic islet inactive enhancer, a minimal promoter and a luc2 gene.
60288pGL4.23 C2_11This plasmid contains a human pancreatic islet inactive enhancer, a minimal promoter and a luc2 gene.
60289pGL4.23 C2_13This plasmid contains a human pancreatic islet inactive enhancer, a minimal promoter and a luc2 gene.
60290pGL4.23 C2_14This plasmid contains a human pancreatic islet inactive enhancer, a minimal promoter and a luc2 gene.
60291pGL4.23 C3_5This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60292pGL4.23 C3_6This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60293pGL4.23 C3_7This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60294pGL4.23 C3_8This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60295pGL4.23 C3_9This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60296pGL4.23 C3_21This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60297pGL4.23 C3_11This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60298pGL4.23 C3_13This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60299pGL4.23 C3_15This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60300pGL4.23 C3_17This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60301pGL4.23 C3_18This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60302pGL4.23 C3_19This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60303pGL4.23 C3_20This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60304pGL4.23 C3_22This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60305pGL4.23 C3_25This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60306pGL4.23 C3_26This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60307pGL4.23 C3_27This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60308pGL4.23 C3_28This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60309pGL4.23 C3_29This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60310pGL4.23 C3_31This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60311pGL4.23 C3_32This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60312pGL4.23 C3_33This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60313pGL4.23 C3_34This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60314pGL4.23 C3_36This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60315pGL4.23 C3_37This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60316pGL4.23 C3_38This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60317pGL4.23 C3_39This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.
60319pGL4.23 C5_12This plasmid contains a genomic fragment that is not active in human pancreatic islets, a minimal promoter and a luc2 gene. Can be used as negative control in reporter assays performed in human pancreatic islets.
60321pGL4.23 C5_14This plasmid contains a genomic fragment that is not active in human pancreatic islets, a minimal promoter and a luc2 gene. Can be used as negative control in reporter assays performed in human pancreatic islets.
60322pGL4.23 C5_15This plasmid contains a genomic fragment that is not active in human pancreatic islets, a minimal promoter and a luc2 gene. Can be used as negative control in reporter assays performed in human pancreatic islets.
60323pGL4.23-GWThis is a modified version of the pGL4.23 vector from Promega, containing a Gateway cassette upstream of the minimal promoter. This vector can be used for for Gateway cloning of candidate enhancer elements. As negative control, use pGL4.23 without the gateway cassette (available from Promega).

Antibodies from Article