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LSM105 CMV-TO-CX3CR1-(noV2)-ADAR2dd(E488Q, T501A) (FLP-IN)

Plasmid

#233397

Purpose

CX3CR1-ADAR2dd(E488Q, T501A) with a short 4 amino acid linker and no V2 tail

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

CX3CR1-ADAR2dd

Expression

Mammalian

Mutation

E488Q, T501A on ADAR2dd

Promoter

CMV

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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LSM068 CMV-TO-CX3CR1-ADAR2dd(E488Q, T501A) (FLP-IN)

Plasmid

#233398

Purpose

CX3CR1-V2-ADAR2dd(E488Q, T501A) with a short 4 amino acid linker and V2 tail

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

CX3CR1-ADAR2dd

Expression

Mammalian

Mutation

E488Q, T501A on ADAR2dd

Promoter

CMV

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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XZ113 CMV-TO-signal-hOXTR-ADAR2dd(DD-E488Q-T501A) (FLP-IN)

Plasmid

#233399

Purpose

human oxytocin receptor-ADAR2dd(E488Q, T501A), no V2 tail

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

OXTR-ADAR2dd

Expression

Mammalian

Mutation

E488Q, T501A on ADAR2dd

Promoter

CMV

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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XZ105 CMV-TO-signal-hOXTR-V2-ADAR2dd(DD-E488Q-T501A) (FLP-IN)

Plasmid

#233400

Purpose

human oxytocin receptor-V2-ADAR2dd(E488Q, T501A)

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

OXTR-ADAR2dd

Expression

Mammalian

Mutation

E488Q, T501A on ADAR2dd

Promoter

CMV

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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XZ142 CMV-TO-signal-B2AR-ADAR2dd(DD-E488Q-T501A) (FLP-IN)

Plasmid

#233401

Purpose

_-2 adrenergic receptor-ADAR2dd(E488Q, T501A), no V2 tail

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

B2AR-ADAR2dd

Expression

Mammalian

Mutation

E488Q, T501A on ADAR2dd

Promoter

CMV

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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YH039 PGK-TO-FKBP-tm-GS-XTEN-ADAR2(DD-E488Q-T501A)

Plasmid

#233378

Purpose

PGK promoter driven FKBP fused with ADAR2dd (E488Q,T501A), with a CD28 transmembrane domain in between

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

FKBP-ADAR2dd

Expression

Mammalian

Mutation

E488Q, T501A on ADAR2dd

Promoter

PGK

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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XZ030 CMV-TO-AVPR2-ADAR2(DD-E488Q-T501A) (FLP-IN)

Plasmid

#233380

Purpose

AVPR2-V2-ADAR2dd(E488Q, T501A) with a short 4 amino acid linker and extra V2 tail

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

AVPR2-ADAR2dd

Expression

Mammalian

Mutation

E488Q, T501A on ADAR2dd

Promoter

CMV

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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XZ362 EF1a-VEGFR2sp-HA-VEGFR2(Ecto+TM)-TS-tdMCP-export

Plasmid

#233381

Purpose

Optimized VEGF-sensing eLIDAR with VEGFR2 ecto+TM domains fused with tdMCP, with Golgi traffic sequence and ER export sequence

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

VEGFR2(ecto+TM)-tdMCP

Tags

HA

Expression

Mammalian

Mutation

WT

Promoter

EF1a

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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LSM104 CMV-TO-AVPR2-(noExtraV2)-ADAR2(DD-E488Q-T501A) (FLP-IN)

Plasmid

#233390

Purpose

CCR6-ADAR2dd(E488Q, T501A) with a short 4 amino acid linker and no extra V2 tail

Depositor

Xiaojing Gao

Article

Zhang et al Nat Chem Biol. 2025 Mar 28. doi: 10.1038

Insert

AVPR2-ADAR2dd

Expression

Mammalian

Mutation

E488Q, T501A on ADAR2dd

Promoter

CMV

Available Since

April 1, 2025

Availability

Academic Institutions and Nonprofits only

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CA-0140 CMVTO-Renin-ECL-CD4-tevs-RXR6.2

Plasmid

#231199

Purpose

ER-retained renin

Depositor

Xiaojing Gao

Article

Aldrete et al Nat Chem Biol. 2025 Jan 15. doi: 10.1038

Insert

Renin-ECL-CD4-tevs-RXR6.2 (REN Human)

Expression

Mammalian

Available Since

Jan. 27, 2025

Availability

Academic Institutions and Nonprofits only

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CA-0151 CMVTO-Renin(H2M)-ECL

Plasmid

#231201

Purpose

Membrane-bound human-to-mouse (H2M) renin

Depositor

Xiaojing Gao

Article

Aldrete et al Nat Chem Biol. 2025 Jan 15. doi: 10.1038

Insert

Renin(H2M)-ECL (REN Human)

Expression

Mammalian

Mutation

L147I, R148H, I203V, L290V

Available Since

Jan. 24, 2025

Availability

Academic Institutions and Nonprofits only

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CMVTO-hIL2 (AV)

Plasmid

#231226

Purpose

hIL2

Depositor

Xiaojing Gao

Article

Aldrete et al Nat Chem Biol. 2025 Jan 15. doi: 10.1038

Insert

hIL2 (IL2 Human)

Expression

Mammalian

Available Since

Jan. 24, 2025

Availability

Academic Institutions and Nonprofits only

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AA498

Plasmid

#231119

Purpose

Fragmid fragment: (guide cassette) ABE activity-based selection CD274 positive control

Depositor

John Doench, David Root

Article

Kaplan et al Nat Genet. 2025 Nov;57(11):2920-2929. do

Insert

sgCD274 + ABE splice-targeting sgRNA

Use

CRISPR

Expression

Bacterial

Available Since

Jan. 16, 2025

Availability

Academic Institutions and Nonprofits only

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AA505

Plasmid

#231120

Purpose

Fragmid fragment: (guide cassette) CBE activity-based selection CD274 positive control

Depositor

John Doench, David Root

Article

Kaplan et al Nat Genet. 2025 Nov;57(11):2920-2929. do

Insert

sgCD274 + CBE splice-targeting sgRNA

Use

CRISPR

Expression

Bacterial

Available Since

Jan. 16, 2025

Availability

Academic Institutions and Nonprofits only

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pTrc-clbS_Ealbertii

Plasmid

#223360

Purpose

Encoding ClbS from Escherichia albertii CB9786

Depositor

Emily Balskus

Article

Silpe et al Nature. 2022 Mar;603(7900):315-320. doi:

Insert

Encoding ClbS from Escherichia albertii CB9786 (Codon optimized for E coli)

Expression

Bacterial

Promoter

pTrc

Available Since

Nov. 8, 2024

Availability

Academic Institutions and Nonprofits only

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pTrc-clbS_Bifido

Plasmid

#223359

Purpose

Encoding ClbS from Bifidobacterium longum subsp. infantis

Depositor

Emily Balskus

Article

Silpe et al Nature. 2022 Mar;603(7900):315-320. doi:

Insert

Encoding ClbS from Bifidobacterium longum subsp. infantis (Codon optimized for E coli)

Expression

Bacterial

Promoter

pTrc

Available Since

Nov. 8, 2024

Availability

Academic Institutions and Nonprofits only

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pTrc-clbS_Samsonia

Plasmid

#223357

Purpose

Encoding ClbS from Samsonia erythrinae DSM 16730

Depositor

Emily Balskus

Article

Silpe et al Nature. 2022 Mar;603(7900):315-320. doi:

Insert

Encoding ClbS from Samsonia erythrinae DSM 16730 (Codon optimized for E coli)

Expression

Bacterial

Promoter

pTrc

Available Since

Nov. 8, 2024

Availability

Academic Institutions and Nonprofits only

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pTrc-clbS_Gibsiella

Plasmid

#223356

Purpose

Encoding ClbS from Gibbsiella quercinecans DSM 25889

Depositor

Emily Balskus

Article

Silpe et al Nature. 2022 Mar;603(7900):315-320. doi:

Insert

Encoding ClbS from Gibbsiella quercinecans DSM 25889 (Codon optimized for E coli)

Expression

Bacterial

Promoter

pTrc

Available Since

Nov. 8, 2024

Availability

Academic Institutions and Nonprofits only

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pTrc-clbS_Snod

Plasmid

#223355

Purpose

Encoding ClbS from Snodgrassella alvi wkB2

Depositor

Emily Balskus

Article

Silpe et al Nature. 2022 Mar;603(7900):315-320. doi:

Insert

Encoding ClbS from Snodgrassella alvi wkB2 (Codon optimized for E coli)

Expression

Bacterial

Promoter

pTrc

Available Since

Nov. 8, 2024

Availability

Academic Institutions and Nonprofits only

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pTrc-clbS_Dickeya

Plasmid

#223351

Purpose

Encoding ClbS from Dickeya dadantii

Depositor

Emily Balskus

Article

Silpe et al Nature. 2022 Mar;603(7900):315-320. doi:

Insert

Encoding ClbS from Dickeya dadantii (Codon optimized for E coli) (CO076_RS11420 Dickeya dadantii)

Expression

Bacterial

Promoter

pTrc

Available Since

Nov. 8, 2024

Availability

Academic Institutions and Nonprofits only

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