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pCMV-myc-Sema4D RNAiR

Plasmid

#51600

Purpose

expresses RNAi-resistant mouse Sema4D with N-terminal myc tag

Depositor

Suzanne Paradis

Article

Raissi et al Mol Cell Neurosci. 2013 Nov;57:23-32. do

Insert

Sema4D (Sema4d Mouse)

Tags

myc

Expression

Mammalian

Mutation

silent mutations between amino acids (approx 275-…

Promoter

CMV

Available Since

April 7, 2014

Availability

Academic Institutions and Nonprofits only
pTA-M+

Plasmid

#249818

Purpose

Expresses Mycobacterium tuberculosis topoisomerase I under the control of the Tet promoter in mycobacteria

Depositor

Yuk-Ching Tse-Dinh

Article

Sandhaus et al Antimicrob Agents Chemother. 2016 Jun 20

Insert

Mycobacterium tuberculosis topoisomerase I (topA Mycobacterium tuberculosis)

Tags

6xHis

Expression

Bacterial

Promoter

Tet

Available Since

March 9, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV.hSynap.(cyto).iGlucoSnFR2.mIRFP670nano3

Plasmid

#244093

Purpose

Cytosolic expression of green glucose sensor with non-responsive mIRFP

Depositor

Tim Brown, HHMI-JRC Tool Translation Team

Article

Marvin et al Sci Adv. 2025 Nov 14;11(46):eadz3889. do

Insert

iGlucoSnFR2.mIRFP670nano3

Use

AAV

Tags

mIRFP670nano3

Available Since

Feb. 27, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV.hSynap.(mem).iGlucoSnFR2.mIRFP670nano3

Plasmid

#244098

Purpose

Plasma membrane targeted expression of green glucose sensor with non-responsive mIRFP

Depositor

Tim Brown, HHMI-JRC Tool Translation Team

Article

Marvin et al Sci Adv. 2025 Nov 14;11(46):eadz3889. do

Insert

iGlucoSnFR2.mIRFP670nano3

Use

AAV

Tags

IgG kappa leader and mIRFP670nano3

Available Since

Feb. 27, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV.CAG.(cyto).iGlucoSnFR2.mRuby3

Plasmid

#244071

Purpose

Cytosolic expression of green glucose sensor with non-responsive mRuby3

Depositor

Tim Brown, HHMI-JRC Tool Translation Team

Article

Marvin et al Sci Adv. 2025 Nov 14;11(46):eadz3889. do

Insert

iGlucoSnFR2.mRuby3

Use

AAV

Tags

mRuby3

Available Since

Jan. 27, 2026

Availability

Academic Institutions and Nonprofits only

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pHR_PGK_ anti-CSPG5 12959 (VL + VH) synNotch

Plasmid

#247513

Purpose

Expresses a synNotch receptor binding to CSPG5

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

Expresses a synNotch receptor binding to CSPG5

Use

Lentiviral

Expression

Mammalian

Available Since

Dec. 9, 2025

Availability

Academic Institutions and Nonprofits only

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pHR-PGK- CDH10#1-synNotch-Gal4VP64

Plasmid

#247503

Purpose

Expresses a synNotch binding to CDH10 (cadherin 10)

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

synNotch receptor using a scFvs binding to CDH10 (cadherin 10)

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pHR-PGK- CDH10#3-synNotch-Gal4VP64

Plasmid

#247504

Purpose

Expresses a synNotch binding to CDH10 (cadherin 10)

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

synNotch receptor using a scFvs binding to CDH10 (cadherin 10)

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pHR_PGK_ anti-CSPG5 12959 (VH+VL) synNotch

Plasmid

#247514

Purpose

Expresses a synNotch receptor binding to CSPG5

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

Expresses a synNotch receptor binding to CSPG5

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pHR_PGK_ anti-PTPRZ CA domain 13058 (VH+VL) synNotch

Plasmid

#247518

Purpose

Expresses a synNotch receptor binding to PTPRZ

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

Expresses a synNotch receptor binding to PTPRZ

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pHR_PGK_ anti-CSPG5 12963 (VH+VL) synNotch

Plasmid

#247516

Purpose

Expresses a synNotch receptor binding to CSPG5

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

Expresses a synNotch receptor binding to CSPG5

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pHR_PGK_ anti-CSPG5 12963 (VL+VH) synNotch

Plasmid

#247515

Purpose

Expresses a synNotch receptor binding to CSPG5

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

Expresses a synNotch receptor binding to CSPG5

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pHR_PGK_ anti-PTPRZ CA domain 13059 (VH+VL) synNotch

Plasmid

#247520

Purpose

Expresses a synNotch receptor binding to PTPRZ

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

Expresses a synNotch receptor binding to PTPRZ

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pEF1α-H2B-HaloTag-FRT

Plasmid

#247338

Purpose

Expresses H2B-Halo under EF1 promoter and can be integrated into FRT site

Depositor

Kazuhiro Maeshima

Article

Nozaki et al Mol Cell. 2017 Jul 20;67(2):282-293.e7.

Insert

H2B (H2BC11) (H2BC11 Human)

Tags

HaloTag

Expression

Mammalian

Promoter

EF1α

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pHR_PGK_ GRM3 13144 VLVH synNotch

Plasmid

#247571

Purpose

Expresses a synNotch receptor binding to GRM3

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

Expresses a synNotch receptor binding to GRM3

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pHR_PGK_ gb128_ BCAN 13138 VLVH synNotch

Plasmid

#247573

Purpose

Expresses a synNotch receptor binding to BCAN

Depositor

Wendell Lim

Article

Simic et al Science. 2024 Dec 6;386(6726):eadl4237.

Insert

Expresses a synNotch receptor binding to BCAN

Use

Lentiviral

Expression

Mammalian

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV.CAGFLEX.(mem).iGlucoSnFR2.mRuby3

Plasmid

#244082

Purpose

Plasma membrane targeted expression of green glucose sensor with non-responsive mRuby3

Depositor

Tim Brown, HHMI-JRC Tool Translation Team

Article

Marvin et al Sci Adv. 2025 Nov 14;11(46):eadz3889. do

Insert

iGlucoSnFR2.mRuby3

Use

AAV

Tags

IgG kappa leader and mRuby3

Available Since

Oct. 24, 2025

Availability

Academic Institutions and Nonprofits only

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pLKO-Tet-On-AHR-shRNA1

Plasmid

#166889

Purpose

Lentivirus for inducible knockdown of human AHR

Depositor

Roland Friedel

Article

Halawani et al bioRxiv [Preprint]. 2024 Sep 14:2023.11.

Insert

AHR shRNA (AHR Human)

Use

Lentiviral

Expression

Mammalian

Promoter

TRE

Available Since

Oct. 1, 2025

Availability

Academic Institutions and Nonprofits only

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pLKO-Tet-On-AHR-shRNA3

Plasmid

#166909

Purpose

Lentivirus for inducible knockdown of human AHR

Depositor

Roland Friedel

Article

Halawani et al bioRxiv [Preprint]. 2024 Sep 14:2023.11.

Insert

AHR shRNA (AHR Human)

Use

Lentiviral

Expression

Mammalian

Available Since

Oct. 1, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV.hSynapFLEX.(cyto).iGlucoSnFR2.mIRFP670nano3

Plasmid

#244100

Purpose

Cytosolic expression of green glucose sensor with non-responsive mIRFP

Depositor

Tim Brown, HHMI-JRC Tool Translation Team

Article

Marvin et al Sci Adv. 2025 Nov 14;11(46):eadz3889. do

Insert

iGlucoSnFR2.mIRFP670nano3

Use

AAV

Tags

mIRFP670nano3

Available Since

Sept. 24, 2025

Availability

Academic Institutions and Nonprofits only

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