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pAAV-Syn-Ace-mNeon2-Kv2.1PR

Plasmid

#195522

Purpose

Green fluorescent, negative response-polarity voltage indicator under the control of synapsin promoter; soma-targeted

Depositor

Vincent Pieribone

Publication

Kannan et al Science. 2022 Nov 4;378(6619):eabm8797.

Insert

Ace-mNeon2-Kv2.1 proximal restriction sequence

Use

AAV

Expression

Mammalian

Mutation

Ace-mNeon 81S; SY linker

Promoter

Synapsin

Available since

Jan. 31, 2023

Availability

Academic Institutions and Nonprofits only

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AAV-GFAP(long)-FLEX-GCaMP7f

Plasmid

#189612

Purpose

Cre-dependent GCaMP7f under the GFAP promoter

Depositor

Martin Riccomagno

Publication

Agnew-Svoboda et al Cell Rep Methods. 2022 Aug 22;2(8):10027

Insert

GCaMP7f

Use

AAV and Cre/Lox

Tags

GCaMP7f

Expression

Mammalian

Available since

Sept. 16, 2022

Availability

Academic Institutions and Nonprofits only

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pAAV-flex-GFP-shRNA-GluN1

Plasmid

#182502

Purpose

Expresses shRNA against mouse NMDA receptor NR1 subunit. Flexed cassette driven by hdc (pan neuronal) gene promoter

Depositor

William Wisden

Publication

Miracca et al J Neurosci. 2022 May 31. pii: JNEUROSCI.

Insert

pan neuronal promoter (hdc basal promoter) driving flexed-GFP-mir30-shRNA NR1 cassette

Use

AAV, Cre/Lox, and RNAi

Expression

Mammalian

Promoter

fragment of histidine decarboxylase gene promoter…

Available since

March 4, 2022

Availability

Academic Institutions and Nonprofits only

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pAAV-SynI-FlpOn-CreOff-TdTomato

Plasmid

#176275

Purpose

Viral vector for expression of TdTomato in cells expressing Flp AND NOT Cre driven by the human Synapsin promoter.

Depositor

Martin Riccomagno

Publication

Ubina et al J Cell Sci. 2021 Oct 15;134(20). pii: 27

Insert

tdTomato

Use

AAV and Cre/Lox

Expression

Mammalian

Promoter

human Synapsin I

Available since

Dec. 17, 2021

Availability

Academic Institutions and Nonprofits only

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pAAV-hSyn-mCherry.3xFLAG.NOS1AP-WPRE

Plasmid

#127864

Purpose

pAAV plasmid expressing an mCherry.3xFLAG.NOS1AP fusion protein under the hSyn promoter

Depositor

Florian Freudenberg

Publication

Candemir et al Eur Neuropsychopharmacol. 2016 Apr;26(4)

Insert

Nos1ap (Nos1ap Mouse)

Use

AAV

Tags

3xFLAG and mCherry

Promoter

hSyn

Available since

Aug. 2, 2019

Availability

Academic Institutions and Nonprofits only

Cited by

2 Articles

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pAAV-CT3G-ER-GFP

Plasmid

#261726

Purpose

All-in-one AAV vector for dox-inducible expression of sfGFP (EF-1α-driven Tet-On 3G, AAV2 ITR-flanked)

Depositor

George Church

Publication

Plesa et al Nat Aging. 2026 Oct;6(10):2057-2073. doi

Insert

sfGFP

Use

AAV

Expression

Mammalian

Promoter

TetOn

Available since

Oct. 14, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV-P3-Alb-mStayGold

Plasmid

#234549

Purpose

To produce AAV with the P3 promoter to express Alb(mouse)-mStayGold(Ando) fusion protein

Depositor

Hajime Hirase

Publication

Knak et al Neurophotonics. 2025 Jun;12(Suppl 2):S22

Insert

Alb-mStayGold

Use

AAV

Mutation

None

Promoter

P3

Available since

Oct. 22, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-P3-Alb-StayGold

Plasmid

#213790

Purpose

To produce AAV with the P3 promoter to express Alb(mouse)-StayGold fusion protein

Depositor

Hajime Hirase

Publication

Knak et al Neurophotonics. 2025 Jun;12(Suppl 2):S22

Insert

Alb (Alb Mouse)

Use

AAV

Tags

StayGold

Expression

Mammalian

Available since

Oct. 22, 2025

Availability

Academic Institutions and Nonprofits only

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AAV-CAG-GRN-HA

Plasmid

#243760

Purpose

AAV plasmid expressing human GRN with a C-terminal HA tag under the CAG promoter.

Depositor

Andrew Arrant

Publication

Nader et al Sci Rep. 2025 Jul 19;15(1):26217. doi: 1

Insert

Progranulin (GRN Human)

Use

AAV

Tags

HA Tag

Promoter

CAG

Available since

Oct. 8, 2025

Availability

Academic Institutions and Nonprofits only

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AAV-pSyn_R-PTEN

Plasmid

#227437

Purpose

Expression of the R-PTEN sensor under the Synapsin promoter in an AAV backbone

Depositor

Tal Laviv

Publication

Kagan et al Nat Methods. 2025 Apr;22(4):764-777. doi

Insert

R-PTEN sensor (Pten Rat)

Use

AAV

Tags

mCyRFP2 and mMaroon

Expression

Mammalian

Mutation

R14G

Promoter

Synapsin

Available since

May 30, 2025

Availability

Academic Institutions and Nonprofits only

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AAV2_CAG_oROS-HT(C199S)_WPRE

Plasmid

#216415

Purpose

Encodes the loss-of-function mutation C199S of genetically encoded, chemigenetic fluorescent peroxide sensor oROS-HT in AAV viral vectors

Depositor

Andre Berndt

Publication

Lee et al bioRxiv 2024.02.06.579232

Insert

oROS-HT(C199S)

Use

AAV

Expression

Mammalian

Promoter

CAG

Available since

April 24, 2024

Availability

Academic Institutions and Nonprofits only

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pAAV-hsyn-dMASS_LF_WPRE

Plasmid

#209766

Purpose

AAV virus production for neuronal expression of dMASS_LF (loss-of-function) under hSyn promoter

Depositor

Andre Berndt

Publication

Rappleye et al ACS Sens. 2023 Nov 24;8(11):4233-4244. d

Insert

dMASS_LF

Use

AAV

Expression

Mammalian

Promoter

hSyn

Available since

Nov. 21, 2023

Availability

Academic Institutions and Nonprofits only

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1529_pAAV-CB-FKBP12-BirA-HA

Plasmid

#208200

Purpose

Express the murine FKBP12-BirA-HA fusion protein in AAV vector

Depositor

Susan Hamilton

Publication

Lee et al Commun Biol. 2023 Sep 14;6(1):942. doi:

Insert

Fkbp12 (Fkbp1a Mouse)

Use

AAV

Promoter

Chicken beta-actin

Available since

Oct. 23, 2023

Availability

Academic Institutions and Nonprofits only

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pAAV-hSyn-rtTA3G-TetOn3G

Plasmid

#250672

Purpose

Drive Tet-ON activator expression from human synapsin promoter for doxycycline-inducible transgene activation

Depositor

Changyang Linghu

Publication

Zheng et al Nature. 2026 Jan 26. doi: 10.1038/s41586

Insert

rtTA3G-TetOn3G

Use

AAV

Expression

Mammalian

Promoter

hSyn

Available since

Jan. 12, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV-UbC-CytoTape-vivo-HA

Plasmid

#250670

Purpose

CytoTape-vivo structural monomer for CytoTape-vivo fiber formation and elongation for mouse brain in vivo applications

Depositor

Changyang Linghu

Publication

Zheng et al Nature. 2026 Jan 26. doi: 10.1038/s41586

Insert

CytoTape-vivo-HA

Use

AAV

Expression

Mammalian

Promoter

UbC promoter

Available since

Jan. 12, 2026

Availability

Academic Institutions and Nonprofits only

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AAV-KrasWT/sgKras/Cre

Plasmid

#99848

Purpose

Expresses Cre-recombinase, a barcoded HDR template that serves as a control for HDR into the endogenous Kras locus, and a Kras-targeting sgRNA to enhance HDR.

Depositor

Monte Winslow

Publication

Winters et al Nat Commun. 2017 Dec 12;8(1):2053. doi:

Insert

Kras (Kras Mouse)

Use

AAV and Cre/Lox

Expression

Mammalian

Mutation

AvrII site (CAAAGG>CCTAGG), PAM/sgRNA mutation…

Available since

Dec. 13, 2017

Availability

Academic Institutions and Nonprofits only

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pAAV-CMV-flex-Unc5cHA-WPRE-SV40pA

Plasmid

#205442

Purpose

production of AAV for cre-dependent expression of Unc5C, tagged with 3xHA at C-terminus

Depositor

Jeremy Kay

Publication

Prigge et al Dev Cell. 2023 Oct 23;58(20):2080-2096.e

Insert

Unc5c (Unc5c Mouse)

Use

AAV

Tags

3xHA

Promoter

mini-CMV (with MVM small intron)

Available since

Oct. 13, 2023

Availability

Academic Institutions and Nonprofits only

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pAAV-CAGGS-Flex/3'USS(553)-GFP

Plasmid

#197888

Purpose

Can be used to generate AAV virus that will express GFP in the presence of Cre including the shortage of a unilateral spacer sequence(USS)

Depositor

Kazuto Kobayashi

Publication

Matsushita et al Cell Rep Methods. 2023 Jan 18;3(2):10039

Insert

GFP

Use

AAV

Mutation

N/A

Promoter

CAG

Available since

March 15, 2023

Availability

Academic Institutions and Nonprofits only

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pAAV-EF1a-double floxed-Gat1-HA-WPRE-HGHpA

Plasmid

#184635

Purpose

Expresses the GABA membrane transporter Gat1 fused to HA, driven by the Ef1a promoter, in a Cre-dependent fashion

Depositor

Nicolas Tritsch

Publication

Melani et al Cell Rep. 2022 Apr 19;39(3):110716. doi:

Insert

Gat1 (Slc6a1 Mouse)

Use

AAV

Promoter

EF1a

Available since

Aug. 9, 2022

Availability

Academic Institutions and Nonprofits only

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VII_pAAV-ProB8-GFP-WPRE

Plasmid

#125928

Purpose

Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

Depositor

Botond Roska

Publication

Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

Insert

GFP

Use

AAV

Promoter

ProB8

Available since

Oct. 31, 2019

Availability

Academic Institutions and Nonprofits only

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