Viral Vectors 101: Pseudotyping
Type
Blog Post
...Broad tropism: VSV-G pseudotyping
A commonly used envelope protein for pseudotyping is VSV-G, or vesicular...one of the reasons VSV-G is used to transduce stem cells and neurons.
However, VSV-G’s broad tropism can... cytotoxicity can vary. For example, the popular VSV-G envelope protein causes cells that it infects to...complement-based killing by anti-alphaGal antibodies. The VSV-G envelope protein is inactivated by serum regardless...vesicular stomatitis virus G protein. VSV-G is a trimeric protein that binds phosphatidylserine and low-density... surface to endocytose into the cell.
The reason VSV-G is so commonly used is that it is good at infecting...and B cells is low. Infection of these cells with VSV-G pseudotyped virus requires the upregulation of ...