We narrowed to 933 results for: KIN

...release IL-36 cytokines. Keratinocytes are the main source of IL-36 cytokines in the skin making it important...the uncontrolled activation of the interleukin-36 (IL-36) cytokine family resulting in the activation ...disease research. This year is our fourth year working with the Rare Genomics Institute by providing plasmid-based...pustular psoriasis is a chronic autoinflammatory skin disease estimated to affect 0.27 to 4.6 per 10,000...surrounding IL-36 biology. “Little is known how IL-36 cytokines actually get out of keratinocytes and induce their...researcher at University Hospital Zurich. IL-36 cytokines are a potent inducer of an autoinflammatory loop... our biosensor repository as we find ourselves lacking several crucial biosensors that would allow us ...

...qualify what kind of “plate” you mean. Without context, it’s difficult to know what kind of plate they...professionals from other backgrounds at conferences or networking events. And if you’re a wet lab scientist who...collaborative lab work. Corralling context and junking jargon I suspected I knew at least one source of...they were talking about during the meetings. And “plate” certainly wasn’t the only problematic word. How...We took steps towards solving this problem by 1) making sure we qualified these words when we discussed...and racks meant we had fewer errors in our LIMS tracking system. Though you might not have to communicate...creating shared experimental protocols. Clarify: Asking for clarification during a meeting can help get...

... worth taking time to honestly evaluate your own style of work and communication before making this important...attention you need? Are you good at asking for help? If you are good at asking for and getting help, size might... toss data-driven reasoning out the window when making decisions. We think scientists make choices based...based on emotions and assumptions. I’m not just talking about simple things like “Which route should I ...members can give you a fuller picture. Consider talking to people in the lab across the hall or in the ...prematurely? Do lab alumni stay in the same field taking projects with them and remaining close colleagues...t choose a mentor that sees you only as a paper making machine. Choose one that is a true mentor, supporting...

...yourself. Instead of thinking “What’s my angle on attacking this problem?”, try thinking “Who can I assemble...researchers do learn MANY transferable skills while working in the lab and by offering advice on areas where...type of team can exist indefinitely. If you’re looking for this type of team in academia, look no further...an imaging core or tissue culture core, you are looking at a process-oriented team serving a particular...you find that there is not someone (or someones) taking on these responsibilities on a team to which you...is certainly necessary, but equally important is making sure all team members understand what roles they... none of that matters. If you are on a team, any kind of team, and you have nagging doubts that someone...

...of my job], so making it a success feels like a real accomplishment.” He started working on them shortly...not sure what his next step should be. He debated taking a position as an application support/sales representative... to me. She was leaving a writing position and looking for someone who might take over. I like writing... a science writer these days. I do some public speaking and a bit of video work for webinars (get tips...shortly after joining IDT when his boss was looking for someone to take over hosting them. Since then, webinars... writing group I am part of is responsible for checking the scientific accuracy of everything that goes...analysis.” Han’s biggest piece of advice for those looking to break into the field of science communications...

...recognize their MANY transferable skills learned while working in the lab and offering advice on areas where you...using creative problem-solving in the lab   Thinking Outside the Box: Individual Approaches Whether...something tangible and applicable to your situation.   Thinking Outside the Box: Team Approaches At some point...same problem. If your lab/company/team is still working towards a culture of encouraging dissent, the next...nine enemies that stand in the way of creative thinking. I won’t go through all nine here, but I’ll discuss...longest tenure, but don’t let that stop you from speaking up.  If your ideas are not well received, understand...work stalls. We become so fixated with the idea of making something the best it can be that it seems impossible...

...back out when you are looking to change positions in the future. Anyone looking for work in today’s job...researchers do learn MANY transferable skills while working in the lab and by offering advice on areas where...student or postdoc forever, and you need to be thinking about what comes next. To that end, one of the...for your career is to expose yourself to other working professionals, and one way to do this is to attend...and connections are how you get jobs! Job fairs Speaking of jobs, it seems like an obviously important ...conference, job fairs bring you face-to-face with working professionals, with the added benefit that most...larger meetings offering resources for students seeking employment within industry or academia; although...

...cells. These cells produce inflammatory cytokines - interleukin (IL)-12 and interferon gamma (IFNγ) - and...help escape immuno-surveillance, and curb cytokine and chemokine production in the tumor microenvironment...their microenvironment by producing C-C motif chemokine 22 (CCL22) and TGFβ. T-regs are suppressive immune...tolerance beyond direct proximity to the tumor; chemokine-aided activation of APCs produces modified dendritic...cancer. Surgical removal causes increases in tumor cytokines like TGFβ and IL-6. However, when strengthened...pathway, VEGF production, and CTLA4 and CD protein blocking. Other molecular targets under research include...response. Antibodies targeting the tumor-augmenting cytokines produced in the tumor microenvironment TGFβ, IL...

...affinity for glutamate but slower kinetics; v857 has faster kinetics but lower affinity) and with a variety...with the end of year approaching. We’re always looking for something to brighten our day, whether it’s... Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission...microscopy. The resulting JEDI-2P has faster response kinetics and increased brightness, sensitivity, and photostability...pYtags illuminate RTK signaling Receptor tyrosine kinases (RTKs) are a major class of signaling receptors...spatiotemporal measurements of receptor tyrosine kinase signaling in living cells. bioRxiv 2022.08.13.503850... al. 2022). iGECInano displays better response kinetics and photochemical characteristics than previous...

...discovered that many of my old suitemates stopped talking to each other if I was not there to arbitrate for...lead to hurt feelings, low morale, poor decision making, and stalled projects. You want to identify and...experiments to address a reviewer’s concerns, you are making your hypothesis stronger. When you share data at...miscommunications in the future. Assumptions: Making incorrect assumptions can be a direct cause or ...or consequence of lapsed communication. Making some assumptions about how something should be communicated...know that a person or team should be involved in making a decision and you see no record of their input... an eye out for the phrase “I assumed they were taking care of that”, because that can indicate confusion...

...addition, it’s really asking a lot of someone to be comfortable on camera while thinking about things like...Science Video Production Specialist, I’m constantly thinking about ways to improve our productions to deliver...we developed a great plan to start consistently knocking out high-quality videos for you all. The next ...products or methods, using metrics and feedback, taking a look at what works and what doesn’t, and trying...Design-Build-Test-Learn cycle adapted for video making.   Cycle One: The Ironing Board Control Center...Center With the pandemic in full swing and everyone working from home, how were we going to film anything? ... prove to be difficult. Shipping the gear, and walking everyone through the recording process was going...

...wise to start working on these skills. Neuroscientists use lots of cool tools While walking around the exhibition...discuss their VR helmets, gait tracking technologies, and brain monitors. Walking around the poster presentation...Neuroscience covers many subfields When I first began looking into the details of SfN17, I expected that almost... mathematical know-how for analysis. If you’re looking to get into neuroscience and you don’t have a background...neuroscience but are afraid you don’t have the right kind of biological expertise to get into the field, there...experiments. This helped reinforce our goals of making more AAVs and educational content to help researchers... suggest a plasmid to us, request that we start making the AAV, or help us produce new educational content...

...Physical scientists have been talking about Click Chemistry since 2001, making use of robust reactions that...inteins are particularly useful for a kind of cellular computation, making possible multiple logic-gated steps...the features that would define a good tool for sticking together biological components. Nearly all of ...tags should be similarly useful across the diverse kinds of proteins that one finds in cells. High yield...HaloTag modules, which can connect proteins to any kind of small molecule probes with different functionalities...increase homology-directed repair efficiency by linking the repair template VirD2 HUH-tag For creating.... Applications are quickly expanding with these kinds of Click Biology reactions. For basic research, ...

...collision that’s taking place between CRISPR technology and synthetic biology, the tools he’s making available.... Addgene: Is this what you are working on now? Voigt: We are working on this now, we have ideas, but ...Massachusetts Institute of Technology has been “working on new experimental and theoretical methods to ...large as natural regulatory networks. Addgene: What kinds of things could we do as genetic circuits become... been putting together very large toolboxes and making them available. We’ll also be submitting parts ...objective is to give people the complete toolbox for taking on very large genetic engineering projects. Addgene...you want. The last few years, we’ve really been making tons of parts and characterizing the software to...

...and foreign nationals working in the life sciences community obtain their working visas, permanent resident...national researchers and entrepreneurs who are looking to continue their careers in the United States....we get elected to Congress, we are tasked with working with US immigration in its current state. As of...discussed in this post benefit from the applicant thinking about the process early, keeping good records,...trained scientist. If the candidate is ultimately looking for a role in a different functional area, then...received sponsorship) then he or she can start working in October of the same year. The Industry H-1B ...of US government grants that the researcher is working under in the lab or has won, awards, media reports...

...expression. Transgenic and knockin mice As the name suggests, transgenic and knockin mice contain an additional...Conditional knockouts or knockins A subset of transgenic mice, conditional knockout/knockin mice, use the Cre-lox...terminology you should be familiar with before working with mouse models, several common techniques used...construct incorporated randomly into the genome, knockin mice have the gene construct inserted at a specific...DNA randomly into the mouse genome. In contrast, knockin strains are generated via homologous recombination...breaks, such as ZFN and TALEN, can used to engineer knockin mice. Co-injection of a targeting vector containing...based systems have been developed for generating knockin mice but because CRISPR/Cas9 engineering favors...

...useful advice about what reviewers in your area are looking for. Remember though, you need to leave them time...The two most important things reviewers will be looking for in your research proposal are originality and...provide different insight into an area - not just working within the established network of your peers. Furthermore...techniques and interact with new people. If you are looking to move to a different university, perhaps in a...re staying in the same lab where you have been working for the last few years, you need to be very clear...Building Your Scientific Network? Check out Our Networking for Scientists Series 4. Become a science communicator...communicator More and more fellowship applications are asking for a 200-300 word explanation of your research...

...before you start. Also, avoid unnecessary talking because talking generates microbe-laden aerosols that may...that can be used as your working stock. This way you can go through your working stock vial by vial before.... UV light exposure is also harmful for eyes and skin so keep the light off when the hood is in use. Wipe...wiped with 70% ethanol immediately. Finally, avoid sticking pipettes into solution bottles directly, rather...familiar with the morphology of the cell line you’re working with so that cross-contamination can be identified...indicates that the cells have grown enough, are making their surrounding media acidic through the secretion... their original condition and can replace your working stock if it gets too old or contaminated. This ...

...between scientific achievements. I've found cooking, gardening, hiking, and photography to be very satisfying...and running very early on. Once your system is working, you should maximize data production with the end...strengthen your new model?  PFs need to be regularly thinking about manuscripts. The other items will follow...even a relatively simple experiment. However, by taking this time, you can help ensure that you understand... feel like it's too much work, they don't like speaking, they don't feel like they get useful feedback...you give your talk or poster to enough different kinds of audiences and if you pay attention to how the...more fundamental reason to give presentations - networking! People get to know you through your presentations...

...and unknown. In fact, in less than two years of walking away from the bench, I have worked for seven different...the science policy community is the best part of working in this profession. The folks who work in science... mechanisms in place to ensure your effective networking---and they’re more accessible than ever thanks...trajectory. If there’s one thing everyone loves, it’s talking about themselves--so don’t be shy and reach out... toward solving one problem. It often requires thinking about a problem in a new way through the integration... in a government setting: drafting legislation, making rules, and implementing the policy within the jurisdiction...to start your science policy journey.  In fact, working in science policy doesn’t have to be a complete...