...neurons are activated when the mouse is placed in a novel context. As a proof-of-principle test, the authors...show that HR blocked neuronal activation in the novel context as determined by reduced c-fos expression...

...adeno-associated virus, herpesviruses, hepatitis B virus, adenoviruses, and human papillomavirus (HPV), to name a few...though the rate of loss greatly depends on cell turnover. Why use integrase-deficient lentiviral vectors...

...are not easily reversible. Late last year, the Akhmanova Lab published a new optogenetic tool for localized...Grigoriev, I., Nijenhuis, W., Kapitein, L. C., & Akhmanova, A. (2022). Opto-katanin, an optogenetic tool ...

...19 testing methods.   Rapid detection of 2019 novel coronavirus SARS-CoV-2 using a CRISPR based DETECTR...for rapid, ultrasensitive and visual detection of novel coronavirus SARS-CoV-2 Sensitivity: 4.6-11 copies...

...capable of inducing the brightest fluorescence (Filonov et al., 2014). Broccoli is twice as bright as Spinach2...9.10 (2014): 2412-2420. PubMed PMID: 25101481. Filonov, Grigory S., et al. "Broccoli: rapid selection ...

...e.g. mScarlet) or infrared fluorescent proteins (Chernov et al., 2017) may improve detection. Since longer...24360272. PubMed Central PMCID: PMC3918502.  14. Chernov, Konstantin G., et al. "Near-infrared fluorescent...

...papers or are brainstorming new technological innovations. Let’s take a look at three historical techniques...past. In the sequencing world, one up and coming innovation is nanopore-based DNA sequencing which reads ...

...flexibility and speed, so you can design, test, and innovate faster than ever. Plus, we've already taken them...potential. Our partners at the Institute for Protein Innovation (IPI) recently released a set of highly-specific...

... can exchange ideas, network, collaborate, and innovate internationally. Why an International Mentorship...Spanish Secretary of Research, Development, and Innovation, D. Carmen Vela, who reiterated the Spanish government...

...DSBs): For small nucleotide edits that introduce a novel restriction site. The region of interest is PCR ...

...strategies for combating cancers. To facilitate innovative cancer research, the Reference Reagents Group...robust CRISPR activators We previously reported on a novel Cas9-based activator developed by the Church lab...-X identified both previously characterized and novel mutants. Hess et al. envision CRISPR-X as not only...

...substrate-linked PEG, biotin, or magnetic beads. In one innovative example, the Zhang lab used SNAP-tag to decorate...Bulleit, R. F., & Wood, K. V. (2008). HaloTag: A Novel Protein Labeling Technology for Cell Imaging and...

...simplifies design of these constructs, allowing novice researchers to quickly and easily start genome ...technology into C. elegans has been a transformative innovation for our community. Developments in mammalian ...

...Hearty TG, Imanian B, Jiang S, Khorasan-zadeh S, Komljenovic I, Laprise S, Liao NY, Lim JS, Lithwick S, Liu...

...V., Fedorova, I., Karneyeva, K. A., Artamonova, D. N., & Severinov, K. V. (2021). Type III CRISPR-CAS ...

...sites of infection or damage (Peters et al. 2008, Chtanova et al. 2008, Kamenyeva et al. 2015)? How do blood...18703742. PubMed Central PMCID: PMC2606057. 2. Chtanova, Tatyana, et al. "Dynamics of neutrophil migration...

...Abudayyeh OO, Gootenberg JS, Wu WY, Scott DA, Severinov K, van der Oost J, Zhang F. 2017. Multiplex gene...

...example, you were the first person to identify a novel protein found in skin cancer and your continued ...career development firm focused on connecting innovative, entrepreneurial companies with like-minded professionals...

...sdAb. sdAbs can have weak signals due to their monovalent nature. Darpins - Darpins are genetically engineered...

...Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids. PloS One...Sabeti, P. C. (2023). Systemic administration of novel engineered AAV capsids facilitates enhanced transgene...