...Balancing research with medical practice as an MD/PhD. Darrel does 20% clinical work 80% research and was... but later got obsessed with research. Chapter 3: How all basic research ends up being translational. ...for Regenerative Medicine accelerates research. Chapter 5: Research currently under way in the Kotton Lab...Chapter 8: The importance of a mix of research approaches. Why researchers should have a mix of high-risk, ...at Boston University Medical School. Darrell’s research focuses on the lungs, and, among other projects...Regenerative Medicine, and within the biomedical research community. Along these lines, Darrell recently...sharing. Listen to learn more about Darrell, his research, and his focus on open science. Listen to the...

...postdoctoral fellow at the Morgridge Institute for Research in Madison, Wisconsin. It is commonly cited that...perform in vitro kinase reactions. Often, however, researchers lack knowledge of the regulatory kinase, access... phosphoserine (as described below) provides researchers with a valuable tool for understanding the contribution...curious anomaly amongst a subset of methanogenic archea: these organisms lacked a classic cysteinyl tRNA... phosphoserine (Sep)-tRNA synthetase enabled researchers to create an orthogonal translation system (OTS...encoding the ORF to be expressed Finally, the researcher needs a plasmid encoding their open reading frame...non-phospho-incorporated proteins purified from the system, researchers can run samples on SDS-PAGE gels containing Phos-Tag...

...has the sequence of the mutated gene the researcher is searching for), then the probe will bind to the sample...of DNA used saving the researcher both time and resources (3). Still, researchers generating transgenic...experiments allowed researchers to identify the location of genes. With this knowledge, researchers were able to...at the end as in standard PCR. This allows the researcher to compare different DNA sequences to see which...In the era before sequencing was commonplace, researchers used restriction mapping to investigate DNA sequence...running the products on an agarose gel allows a researcher to properly orient specific fragments of a DNA...This approach to studying DNA sequences helped researchers at a time when sequencing was still in the early...

...those by researchers hoping to increase community participation in new precision medicine research. A willingness...entails a lot of researching and writing – following the latest developments in genetics research, their applications...work in these fields of research, what often concerns them the most about research is its implications for...possibility of benefiting from the fruits of scientific research, and prevent technological advances from exacerbating...to dark episodes in the history of eugenics and research misconduct. Past ethical breaches such as the ...used to being very focused on narrowly-defined research questions in our field of interest. We often communicate...and awareness of issues outside of your field of research will allow you to better engage these diverse ...

...biomedical research: recommendations from the Future of Research Chicago Symposium F1000Research, 2016. Kyle...their careers (McDowell et al, F1000Research, 2014; Dolan, F100Research, 2016). These events have also...Shaping the Future of Research: a perspective from junior scientists."F1000Research 3 (2014). Pubmed PMID...Symposium and Workshop, organized by Future of Research, Academics for the Future of Science, and the ... More information can be found at http://futureofresearch.org/advocating-for-science-boston-2016/. Sign...Symposium Boston 2016 Changes since the Future of Research Symposia Ongoing challenges facing the scientific... 2014; Taylor, eLife, 2016). Several Future of Research (FoR) symposia held across the USA during this...

...required to study SARS-CoV-2, but with many academic research labs closed during the pandemic, it’s hard to ... are crucial for the advancement of SARS-CoV-2 research because they provide rapid access to validated... and much more have been critical for pandemic research. Image from Reproducibility for Everyone. Case...broad use and are now important for accelerating research into this virus. One such example is cell lines...repository for a variety of materials for life science research, including over 4,000 cell lines. Seventeen of...this study came from the Japanese Collection of Research Bioresources Cell Bank, part of the National Institutes...Nutrition in Japan. These results  will help researchers choose the best experimental model for further...

...reproducibility at some point. Usually it comes up when a researcher decides on a new project and begins by trying...variation in experimental conditions will derail a research program (think a subtle difference in mouse chow...sure you do what you can to help your fellow researchers advance science overall. Communication is the...inadequate information about what the original researchers actually did. Admittedly, the differences are...they come to light, it’s clear that what the researchers thought was a problem in fact was not, and it...in an accessible and consistent way so other researchers can use them, to making sure that methods and...to being open and willing to share with other researchers to help them troubleshoot and understand. All...

...Member and lead researcher at Imperial College London, Dr. Tom Ellis. Dr. Ellis does research in synthetic...chromosomes, and obstacles to becoming an academic researcher. Listen to the interview with Tom Ellis Podcast...breakdown Intro: How Tom ended up in academia and his research goals. From grad school to a startup and back ...in academia. Learning how to build a lab and a research program and difficulties with work-life balance... synthetic biology to the UK with foundational research, training, startups, and real applications of ..., disciplined, and open techniques. Chapter 4: Research projects underway in the Ellis lab including yeast...adoption of synthetic biology techniques in biology research as can already be seen with things like DNA synthesis...

...immunological research. Here the Zhou group presented Opto-CRAC which allows a researcher to control immune...Research tackling questions in the fields of Cancer, Inflammation and Immunity, as well as various combinations... (so called “Immuno-Oncology”) is exploding. Researchers are increasingly able to harness the body’s immune...impression from this conference was that Cancer Researchers and Immunologists are coming together to tackle...Michael Karin from UCSD: “The problem with cancer research is that it is too fragmented and focused ... to...conference which reflect how cancer/immunology researchers are preparing and carrying out this multi-pronged...presented study analysed a model of hepatocellular carcinoma, a cancer which can develop from a state of chronic...

... Genes:       BRG1(SMARCA4) BAF170 (SMARCC2) ARID1A   Chromatin research articles with plasmids...it’s true that adding histones and chromatin architecture to every diagram portraying some aspect of eukaryotic...when I recently attended the 2018 Chromosome Architecture and Chromosome Organization Keystone Symposium...but also specifically study it. They might be researching enhancer elements that control the transcription... or indirectly--many other areas of biological research. If you’re looking for resources that will help...posters I saw at the 2018 Keystone Chromosome Architecture and Chromosome Organization. These aren’t the...Kerstin Bystricky Courtney Hodges Sharon Dent Archa Fox Elaine Fuchs Kai Ge Robert Kingston Thoru ...

...perform research there temporarily. The length of stay could be from a month to a year. The researcher remains...visit   Design and communicate a research plan Your time at the new research site is limited, and we all know...collaborations and fresh perspectives. For trainee level researchers, it can expose them to a new institute and mentor...lab So, you’ve identified a gap or need in your research and decided you want to pursue a visiting position...your lab collaborates with that can fulfill your research needs, that is probably the easiest path. Some...programs are often great choices if they fit your research needs. What are your options if neither of these...just reach out to start the conversation. Many researchers are open to sharing knowledge and establishing...

...standardized process of good research practice: computer simulations, in vitro research, animal models, and several...actively being experimented on, too.) However, as research published on December 13 shows us, CRISPR/Cas9...additional public fora for data review, and more lab research could be used to bring scientists and the public...for proof that this model of public involvement, research, and consensus can happen. We just have to look...Wellcome Trust funded a center for mitochondrial research to investigate the scientific possibility, safety...mitochondrial disease;” The Nuffield Council began their research into both novel and previously established ethical...Nuffield Council emphasized, the key to moving research from bench to bedside is, in addition to thorough...

... awardees and their research. These researchers span four continents and research diverse topics including...scientific resources, equipment, and plasmids to researchers in resource-limited settings. More specifically...Labs plasmid grant provide plasmids to these researchers. In the third round of the Addgene-Seeding Labs...more about the five awardees and their promising research projects.   Understanding drug resistance mechanisms... tuberculosis care and control. In her current research, Sheen aims to identify new genes related to PZA-resistance...bacterial engineering using CRISPR on our blog). Her research should provide us with a better understanding ...field of bacterial and fungal pathogenesis. Her research focuses on a collection of pathogenic Klebsiella...

...not just "research and publications” What are the skills you developed through your research? Don't simply... from the research itself, but from what was necessary in order for you to do your research. For example... your publications, academic performances, and research experiences, you now have merely two pages to ...simply write about the research you did. Emphasize the skills. If you studied astronomy or bioinformatics...on these skills. The only exception is when the research topic you have done is closely related to the ...are applying for, in which case talk about your research, as an understanding of the topic will give you...How about facilitating a collaboration between research groups? Perhaps you had some supervisory experience...

...Duedu, a researcher at the University of Health and Allied Sciences in Ghana. He’s done research at a number...distribute plasmids to researchers in developing regions and thereby accelerate their research. Kwabena came across...learning and doing research at Novartis. Listen to learn how Kwabena plans to use his research experiences as...molecular biology research programs. 30:57 - 40:16 : Kwabena's public health research, the HEAD outreach...work in Ghana - Building a bioresource to attract research funding. Using current resources to develop microbiology...about dietary health. 40:17 - 44:14 : Microbiome research - working with bacterial communities both on the...down and talk with us.  Kwabena Duedu, PhD is a researcher at the University of Health and Allied Sciences...

...)” — Jim Woodgett, biomedical researcher at Lunenfeld-Tanenbaum Research Institute, posting about Addgene...for the research community once more. Our ready-to-use viral vectors were useful for researchers wanting...pcDNA-p160MBP, while the first request for a kit came on March 9, 2005. It took almost six years to reach our first...molecularbiology.   Oh, to be young again! Addgenie Marcy (now our Sr. Director of Production) pie-fully celebrating...10 year anniversary.   Expanding our work In March 2015, Addgene reached the 500,000 plasmids distributed...launched the Blue Flame Award, which recognizes researchers who have at least one plasmid deposited at Addgene...-19 pandemic, and Addgene pivoted to support researchers combatting the virus. Our COVID-19 collection...

...scientist, perhaps the most important part of your research is communicating the results of the work. Yes,...other: from formal mechanisms like publishing a research article, presenting a conference poster or talk...drafted. Preprints were one of the key routes for researchers to share information about the emerging SARS-... recognition for their efforts, inspire future research, and increase their impact. Open Access and Transparency...process among a few individuals.  Early-career researchers especially enjoy the ability to post a preprint...and other modes of scientific communication. Researchers often post a preprint at the same time as, or...communication needs. The most often-cited reasons researchers might not post a preprint are reluctance to share...

...and its 8-bp barcode, respectively. Once cloned into the storage vector, the pooled, barcoded gRNA library...The CombiGEM platform provides a means to create barcoded gRNA libraries that can be used to combinatorially...restriction digestion and ligation steps to build barcoded lentiviral plasmids containing one or more gRNAs...quantitatively analyzed by sequencing its set of barcodes. CombiGEM is highly flexible and can accommodate...thus be tailored to address the users’ specific research questions. CombiGEM has been successfully applied...Thanks to the tremendous efforts made by various research teams to build and constantly improve gRNA libraries...! Figure 1: Strategy for assembling the barcoded gRNA library pool. (Adapted from Wong et al., ...

...doing your research in a group or facility that is a world leader in your chosen area of research (either... this already!” But, you do need to be able to research and write your application, then give it to someone...application is rushed (whether the idea isn’t properly researched / developed or the application is full of typos...important things reviewers will be looking for in your research proposal are originality and relevance. When reading...? This can sometimes be tricky, as most of our research builds on ideas and findings from our own or other...because it is the best place in the world for your research to rapidly progress. Need Help Building Your Scientific... asking for a 200-300 word explanation of your research for non-scientists. Most fellowships are funded...

... the search of phages for therapy Phage Directory started out as a directory of phage researchers and ... Zheng also saw the need to archive phage reagents. If a phage researcher retires, it's likely that the...whirlwind three days in November 2017. #Phage researchers! I am working with a team to get Burkholderia...be sent out to the directory earlier, but the researchers in the directory are volunteering their time ...information was very fragmented. A particular phage researcher may only know how to prepare phage for one application...another or they may have only used phage in basic research but not therapeutically: not all labs in Phage...the phages are lost if they are not archived. “It’s very sad because it’s years of work,” Sacher says....