We narrowed to 599 results for: arl
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  TypeBlog Post...Alpha variant), B1.1.298, and B.1.429 (Epsilon), nearly as well as they could for the wild-type. However...TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D,...
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  New and Upcoming Viral Vectors - December 2019TypeBlog Post...We have also packaged hChR2(H134R) plasmids from Karl Deisseroth’s lab, which includes pAAV-hSyn Con/Fon...WPRE-SV40 124650 AAV9 pAAV-CamKIIa-C1V1(t/t)-mScarlet-KV2.1 55645 AAV5 pAAV-hSyn Con/Fon hChR2(H134R...
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  Donations from Addgene to Yield Answers for Rare Disease ResearchersTypeBlog Post...by mutations in the OCRL1 gene that leads to the early death of young patients as their kidneys fail. The...interested in XP out of a desire to understand the early events in the transformation of healthy cells into...
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  Creating accessible biology activities in schools with BioBitsTypeBlog Post...thinking: I wish I had this kind of experience earlier! After all, students build circuits in physics... about operating the rest of the car as well. Similarly, cell free expression systems contain all the ...
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  Celebrate National Book Month with AddgeneTypeBlog Post...insects, mammals, and plants, among others. I particularly enjoyed the emphasis that microbes are neither...last 8 years. Since then, we’ve read books across nearly every genre you can imagine: gothic, mystery, sci-fi...
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  Fluorescent Protein Travel Awards - Protein Variants, a Serotonin Sensor, and an Artificial Leaf Replica SystemTypeBlog Post... 2017. These travel awards are intended to help early career scientists attend a conference of their choice...evidence suggests that it is incredibly important for nearly every aspect of life.” Unger began with the a bacterial...
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  Plasmids 101: Gram Negative and Positive BacteriaTypeBlog Post...decolorized as gram negative. A German scientist, Carl Weigert, later expanded on Gram’s discovery, adding...resources. Bruckner, M. Gram Staining. https://serc.carleton.edu/microbelife/research_methods/microscopy/gramstain.html...
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  Using CRISPR/Cas9 to Edit Disease Out of the GenomeTypeBlog Post...They are targeting the genes responsible for both early onset and late onset AD. In this study, the group...autosomal-dominant mutations that have been connected to the early onset of Alzheimer’s disease, as well as those that...
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  The MTA at AddgeneTypeBlog Post...MTAs by the Provider and Recipient (in Addgene parlance, the depositor and requestor) organizations. Over...depends on things being organized, tracked, and clearly communicated. And that’s where MTAs, and similar...
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  Crowdfight, a Platform to Boost Scientific Collaboration During COVID-19 and BeyondTypeBlog Post... neutralize the SARS-CoV-2 virus. But while the early results were promising, the researchers did not ... the preprint repository BioRxiv. This example clearly illustrates the power of collaboration, which despite...
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  Addgene Welcomes John Doench to the Advisory BoardTypeBlog Post...specificity in the miRNA regulatory process. This early research is still relevant to his work at the Broad...screens to learn more about cancer biology in Ed Harlow’s group at Harvard Medical School and then applied...
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  Plasmids 101: Inducible PromotersTypeBlog Post...between cell types or organisms, promoters are similarly variable. Bacterial promoters only work in prokaryotic...related species from which they were derived. Similarly, the various eukaryotic cell types (mammalian,...
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  Quick Guide to Working with Drosophila Part 3: Genome Engineering in FliesTypeBlog Post...research (3). The sky is the limit. As mentioned earlier, even genes not found in Drosophila can be studied...immunology PhD at Harvard University. He has had nearly a decade of experience working with Drosophila ...
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  Expanding the Targeting Scope and Editing Efficiency of Adenine Base EditorsTypeBlog Post...Therapies: CRISPR, Stem Cells, and Beyond meeting earlier this month. Another issue that arises for base...cannot be expressed until the base editor corrects early stop codons within T7 RNAP. A phage encoding the...
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  Behind the scenes: Addgene’s new search engine and moreTypeBlog Post...results. The footer and improved menus we launched earlier in the year, as well as our redesigned homepage...categorization of our information in order to more granularly customize the search engine, and a scoping mechanism...
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  Hot Plasmids - June 2019 - Optogenetics, Acoustic Reporter Genes, microRNAs, and the CRISPR-Cas9 system CHIMETypeBlog Post...miRNA reporter podcast segment Discovered in the early 1990’s, microRNAs (miRNAs) are recognized as important...analysis of immune cells has been a gap in the field. Arlene Sharpe’s group at the Harvard Medical School developed...
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  Antibodies 101: IsotypesTypeBlog Post... in Health and Disease. 5th edition. New York: Garland Science; 2001. Structural variation in immunoglobulin... in Health and Disease. 5th edition. New York: Garland Science; 2001. The distribution and functions of...
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  Viral Vectors 101: Inverted Terminal RepeatsTypeBlog Post...because they demonstrate high promoter activity (Earley et al. 2020), but non-AAV2 ITRs can be used to ...microorganisms1202031038399714. PMID: 38399714. Earley, L. F., Conatser, L. M., Lue, V. M., Dobbins, A...
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  How to Keep a Lab Notebook for Bioinformatic AnalysesTypeBlog Post...inspired you to perform this analysis. Having a clearly stated, specific goal for each analysis will help...student at University of Pennsylvania. She is particularly interested in science communication and epigenetics...
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  Advice for Starting a Biotech Company from a Grad Student turned EntrepreneurTypeBlog Post...best, wins. He explained that entrepreneurs must clearly communicate their idea at various levels of complexity...works. “We use functional spectrometers from the early 1990s that were free and free to repair.” If the...