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  2. Build Your CRISPR Vocabulary

    Type
    Blog Post
    ...bacterial chromosome that stores a genetic record of previously encountered foreign nucleic acids. The unusual...CRISPR–Cas immunity and genome editing enzymes. Nature Reviews Microbiology, 20(11), 641–656. https://doi.org/...

  3. Year of the Camelid: Antibody Style

    Type
    Blog Post
    ...the Camelid family, I wanted to take a moment to revisit some of the ways these animals have impacted humans...Odongo S, Radwanska M, Magez S (2023) Nanobodies: A Review of Generation, Diagnostics and Therapeutics. Int...

  4. Antibodies 101: Affinity Tags

    Type
    Blog Post
    ...and the species they are compatible with are all reviewed here. What are affinity tags? Affinity tags are...chromatography requires proper folding of the tag, which prevents insoluble fusion proteins from being purified ...

  6. New CRISPR Web Resources and #12DaysofCRISPR Recap

    Type
    Blog Post
    ...Since the start of the CRISPR revolution, Addgene has distributed over 100,000 CRISPR plasmids. But that...genome, thus providing an avenue for temporary/reversible CRISPR modification. In addition to these subpages...

  8. Running for Rare Disease, Running for FOP, Running for AJ

    Type
    Blog Post
    ... with inappropriate activin-ACVR1 interactions prevents FOP bone growth in mouse models. As this biologic...Resources on the Addgene Blog Learn about Addgene's Previous Work with Rare Disease Researchers Check Out Potentiall...

  9. RUBY-Red Siliques

    Type
    Blog Post
    ...CRISPR construct needs to be segregated away to prevent continued production of new alleles or off-target... generation when CRISPR needs to be removed to prevent further editing, then green offspring can be selected...

  10. Antibodies 101: Epitope Availability

    Type
    Blog Post
    ...other hand, if it opens up an epitope that was previously hidden, an antibody might suddenly work that ...denatured, allowing the antibody to bind to a previously hidden epitope (right). Created withBioRender.com...

  13. Comparing Cas9 to NgAgo: Can the Argonautes Best CRISPR?

    Type
    Blog Post
    ...context, it’s hypothesized that base removal helps prevent the invading genome from “recovering” its original...cannot switch guides. While this fidelity would prevent other small nuclear DNAs from binding NgAgo, it...

  16. Addgene's Top 10 Blog Posts of 2015

    Type
    Blog Post
    ... need to get started using plasmids and the revolutionary CRISPR technology in their own labs. We’re overjoyed...new technologies that will bring about the next revolution in biological research. We’re incredibly happy...
Showing: 321 - 340 of 710 results