...vectors. AAV Types Serotypes AAV serotypes are AAV variants that differ in their tropism — that is, the types...determined by naturally occurring differences in the variable regions of the virus capsid. Thirteen human and...vectors for in vivo applications. Other Engineered Variants Hybrid capsids Hybrid capsids are engineered capsids...successfully employed to engineer new rAAV capsid variants, such as systemic capsids. A systemic capsid is...also been employed to engineer an rAAV serotype variant able to display neuronal retrograde transport, ...D. V., & Karpova, A. Y. (2016). A designer AAV variant permits efficient retrograde access to projection...