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Find out how you can use new CRISPR tagging plasmids from the Allen Institute for Cell Science to tag your cellular structure of interest.

SapTrap improves CRISPR genomic tagging in C. elegans by offering scientists an easy one tube assembly reaction to generate high-throughput targeting vectors.

Addgene scientists perform standard quality control for AAVs. But we are also going one step further with next-generation sequencing (NGS) of the viral genome.

CRISPR genome editing often proceeds through NHEJ or HDR but microhomology-mediated end-joining (MMEJ) has many benefits - read about them here.

Learn all about CAPTURE - a new CRISPR-based technique to study regulatory elements in their native chromatin contexts.

Read on to learn more about this technique to isolate specific genomic regions using CRISPR.

Find tips for transforming arabidopsis with your plasmid construct of interest.

Learn how you can use the Spaghetti Monster fluorescent protein (smFP) tags for neuronal tracing and multicolor labeling of brain structures.

Find materials useful for neurodegeneration research.

Learn about what sequencing technologies the quality control team at Addgene uses to maintain a high standard of plasmid and viral vector quality.

Find GCE synthetase plasmids, target plasmids, and bacterial strains useful for expanding the genetic code in bacteria and mammalian cells.

Browse Ginkgo Bioworks plasmids to express SARS-CoV-2 viral proteins in several expression systems.

Plasmids from the Structural Genomics Consortium (SCG), which are primarily used for determining protein 3D structure and crystallography.

Use the mRNA expression FlowCode plasmids for barcoded expression of mRNAs of interest, for use in large-scale multiplexed in vivo mRNA expression screens.

Learn about antibody engineering, including what it is and why we like it. Deep dive into antibody directed evolution techniques, and learn about Addgene's partnership with the Institute for Protein Innovation (IPI).

Browse Addgene’s curated list of CRISPR resources and references, including gRNA design tools, CRISPR FAQs, and community forums.

Need help with the plasmid deposit process at Addgene? Consult this post for an in-depth walk through the entire process.

Fourteen years after Cas9, CRISPR has moved beyond DNA cutting. Read Addgene's recap of CRISPR Frontiers 2026, covering programmable gene insertion, RNA-sensing cell killing, and next-gen base and prime editors.

If you can't find a validated antibody for your flow experiment, this blog post can help you validate your antibodies yourself.

Learn about the basics of molecular biology, including molecular genetics, plasmids, sequencing, and more.