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...A 2017 survey found that many researchers feel they lack formal training in a variety of transferable...out to fill this gap by both highlighting that researchers do learn MANY transferable skills while working... into play while puzzling through your broader research questions and designing future experiments. Being...While I was in graduate school and beginning to research non-academic careers, I always felt that descriptions...when you’re faced with yet another hurdle in your research journey.  What are ‘problem solving skills’? As... about the world. You might do some background research to better understand it and come up with several... of your skill set later on. If you are new to research and the lab, you may not be able to carry out ...

...represents a unique funding model in nuclear receptor research, and has generated a set of comprehensive datasets... questions in nuclear receptor and coregulator research. Our Q-PCR datasets, for example, document the... today.  The sheer abundance of these critical research tools is a double-edged sword, however, and has...burden associated with identifying plasmids in the research literature and acquiring them in a timely manner...to the problem of sharing plasmids, providing researchers with a one-stop shop for plasmids and vectors...vectors, and making them available to all researchers for a reasonable fee. We at NURSA recognize the importance...importance of this service to the NR research community and, accordingly, the new version of the NURSA website...

...off-target cleavage events. Unbiased techniques search the whole genome for off-target sites irrespective... in concert, these approaches can provide the researcher with a reasonable level of certainly that the...sgRNA. This is a good starting point for most researchers as it provides a list of putative off-target ...can later sequence for mutations. One method a researcher can use to test predicted off-target sites following...to perform these validations as translational researchers begin to use CRISPR as a therapy. Low frequency... effects may generate irreproducible data in a research setting, but these events could have disastrous...off-target prediction algorithms, their genome-wide search criteria are not exhaustive. Mismatch tolerance...

...on a stochastic search algorithm rather than pre-designed sets, so identical searches can return multiple...particularly for high-complexity reactions? The researchers over at New England Biolabs® thought otherwise...design (DAD) to build out three tools to help researchers design high-fidelity Golden Gate Assemblies and...three tools developed, outlined below, allow for researchers to select large sets (with overhangs that violate...You can define the number of fragments, and the “search windows” you’d like the tool to use to identify... can exclude specific sequences or set a narrow search window for a site—or sites—that must be used. Each...necessarily require cycling. The Pros and Cons Researchers used the tools above to complete a 52-piece assembly...

... most commonly used research tools in scientists’ pockets. They allow researchers to identify and isolate...an antibody that will be essential to your new research project, but unsure which one will mark your target...bind to the target). Unreliable antibodies cause research that cannot be reproduced and projects that cannot... with collaborators and support from the Brain Research Through Advancing Innovative Neurotechnologies...Dr. Wu please contact us here! Ava Shipman is a research assistant in lab of Zhuhao Wu at the Icahn School...Reproducibility: Standardize antibodies used in research. Nature 518, 27–29 (2015). https://doi.org/10.1038...The Economics of Reproducibility in Preclinical Research. PLoS Biol 13(6): e1002165. https://doi.org/10.1371...

...students work closely with local researchers to learn about their research while creating physical models...graphics packages were soon developed that allowed researchers to create stunning, interactive images of their... only wonder what I am talking about. How do researchers use physical models of protein structure? We ...been creating physical models of proteins for researchers for the past fifteen years. On those occasions...following sequence of events plays itself out: The researcher breaks eye-contact with any other human in the... and to create custom models of proteins for researchers. Modeling CRISPR We were excited when Jacob Corn...strand. And this is why we love working with researchers on a model. The little knowledge that we have...

...plasmid from our search page (check out this video for a walkthrough of the ways you can search our website...trail at the top of any plasmid page gives the hierarchy of web pages the plasmid page is nested in. You...website). A quicker way to find this plasmid through search is... The Addgene plasmid number: This is the unique...know the catalog number of the plasmid you are searching for, this is the quickest and easiest way to find...than 50; and blue, more than 100 times! When you search for plasmids on our website, one of the available...see if the plasmid would be useful for their own research, and helps requestors use the plasmid in their...citations for Addgene plasmids you have used in your research! Sequence information: Depositors may provide ...

...longer than we’ve been studying it and, now, researchers are exploring ways to bolster and modulate our...protein blocking. Other molecular targets under research include TIM-3, LAG-3, STAT-3, EGFR, CD20 and CD73...to activate them are a few methodologies being researched. Apoptotic and necroptotic tumor cells have also...engineering have played a huge role. For instance, researchers are genetically altering tumor cells and immune... treatments enter the clinic, physicians and researchers are learning much about how treatment regimens... made more effective. Some important factors researchers are beginning to focus on include: Cell heterogeneity... important questions in this exciting field of research. One of the most important: How will cancers evolve...

...acids research 21.15 (1993): 3601. PubMed PMID: 8346047. PubMed Central PMCID: PMC331480. 3. García-Nafría... post was contributed by Jake Watson and Javier García-Nafría from the MRC Laboratory of Molecular Biology...cloning protocol In Vivo Assembly (IVA) cloning (Garcia-Nafria et al., 2016) uses the bacterial recombination...thanks to our guest bloggers Jake Watson and Javier García-Nafría from the MRC Laboratory of Molecular Biology...Biology. Jake Watson is a postdoctoral researcher in neurophysiology at the MRC Laboratory of Molecular...synaptic transmission and plasticity.     Javier García-Nafría is an investigator scientist at the MRC ...    Follow them on Twitter @jakefwatson and @JGarciaNafria.  References 1. Jones, Douglas H., and Bruce...

...immunotherapy, but this research is still in the pre-clinical/early clinical stages. Researchers are also working...vector history and components In the early 1990s, researchers developed viral vector systems based on retroviruses...other difficult-to-transfect cells. Lentiviral barcoding libraries have been used for complex applications...response, it should come as no surprise that researchers are interested in developing these vectors for...vectors have become standard in gene therapy. Researchers have also developed integrase-deficient lentiviral...come a long way since the 1990s, both in terms of research impact and safety. Many of Addgene’s most requested...Virus Biosafety Find Lentiviral Vectors for Your Research  ...