We narrowed to 434 results for: pme

...tumors and cancer. The immune response to the development of tumors is a complicated and dynamic phenomenon... Equilibrium - In a process analogous to the development of drug resistance in bacteria, the tumor cells... onset of cancer. Similar patterns of cancer development are observed in autoimmune disorders. Chronic...autoimmune disorders is also known to precede cancer development, for example, inflammatory bowel disease is associated...in the various types of cancer will fuel the development of immunotherapeutics. There are still many important...

...pathways that are worth investigating for drug development. Due to the difficulty of drugging some targets...occur, such as in the context of a specific developmental phase. As CRISPR keeps advancing, so will drug..., et al., Cornerstones of CRISPR-Cas in drug development and therapy. Nat Rev Drug Discov (2017) 16(2)...CRISPR Plasmids and Resources CRISPR History and Development for Genome Engineering    ...

...on setting SMART goals using a Development Plan template. A Development Plan or mentoring journal will...perhaps, asked someone to support your career development as your mentor. How do you make the most of this... reap rewards in the form of reaching career development goals. Check out Joanne's Reddit AMA Add a ...

...programs provide support for academic career development, it's often left to students to identify and ...career-planning platform called the Individual Development Plan (IDP) and uses it to match qualified scientists...approaches for scientific tool and technique development. However, careers outside of the lab highlight...career planning tools such as the Individual Development Plan to generate a list of potential professions...

...Koeris, co-founder and current VP of Business Development & Operations of Sample6, for advice on how to...months in graduate school focusing on concept development and participating in business competitions. When... COO, then moved on to become VP of Business Development & Operations. Starting a biotech company ...money. Moreover, many universities throw out old equipment that still works. “We use functional spectrometers...

... and metabolic reprograming influence tumors development? Being pathological active regions, microenvironments...Witkiewicz et al., 2009) which contribute to the development and spread of cancer cells. Besides these stromal...CAFs are altered fibroblasts and promote the development and metastasis of tumors through inciting inflammation...tumor may seem to take center stage in cancer development, the microenvironment backstage play just as ...

... involved in a broad range of reproductive, developmental, metabolic, and immune response programs. NRs... so would not have been possible without the development of a vast number expression and reporter plasmids...exchange of these vectors between laboratories. The development of the transient transfection platform for assaying...transcriptional activity, for example, was a key development in the functional characterization of NRs and...

...elements were the starting point towards the development of the first cytosine base editors from Alexis... base editing scope and efficiency Since the development of BE3, many research groups have made improvements...guanine (Thuronyi et al., 2019). Following the development of adenine base editors (discussed next!), RNA...constrained by PAM availability in the genome. So the development of near-PAMless Cas9 variants significantly expands...CRISPR 101: RNA Editing with Cas13. Finally, the development of prime editing, which uses a different mechanism...

...zebrafish articles published there as well.   Worm Development Dynamics Database (WDDD) The WDDD aims to acquire...computational methods to better understand animal development (Kyoda et al., 2012).  C. elegans plasmid tools...PMC6576255. Kyoda, Koji, et al. "WDDD: worm developmental dynamics database." Nucleic acids research 41...conditional protein depletion in C. elegans." Development 142.24 (2015): 4374-4384. PubMed PMID: 26552885...

...and rare, but severe, symptoms, including the development of fetal microcephaly and Guillain-Barré syndrome...health emergency and called for the fast-tracked development of diagnostics. Mostly transmitted by Aedes mosquitoes...timescale. Our article ultimately reported the development of a rapid design and prototyping pipeline that...necessary to advance the technology through product development, the regulatory process, and manufacturing so...

...Kucera is a Principal Development Scientist of Applications & Product Development focusing on DNA cloning...the ordered assembly of the target construct. Development of Golden Gate Assembly test systems Our research... Eric Cantor is a molecular biologist and a Development Group Leader overseeing a team bringing new products...

...18.4 (blue), 5.8 (red) 2.7/4.7 3.9 h (red) pMedium-FT-N1 pTRE-Medium-FT pBAD/HisB-Medium-FT Slow-FT...subcellular location, start of gene expression, development of a cell structure, etc). FP timers should therefore... therefore find use in studies of animal development where events like the patterning of nascent tissues...fluorescent protein DsRed for double labeling and developmental timer of neural fiber bundle formation." Journal...

...opportunity to talk with Provost recently about his development of what is now commonly termed a Course-based...progenitor cell maintenance in planarians in Developmental Biology (Kimball et al., 2020). Benefits and... pathway to diversify science. Evolution and Development. 24(5):127-130. Kimball, C., Powers, K., Dustin... progenitor cell maintenance in planarians. Developmental Biology. 457:119-127. Knutson, K., Smith, J....

...last several years, my lab has been working on development of technologies for biochemical analysis of genome...in biology. Therefore, my lab is dedicated to development of new biological technologies. The locus-specific... we've made some contributions in technology development in biology and hope to develop more in the future... of the game. In this regard, I believe that development of new technologies may be very effective in ...

...and cellular biology, this happens through the development of tools that exploit and expand our current ...which we're featuring in today's blog. Cas7-11 Development and Discovery As part of their quest to find,...Cas systems opens up the potential of further development of low-toxicity RNA editing tools.   Fig...embryonic stem cells and glioblastoma cells. PASTE Development and discovery The first generation of CRISPR ...

...University of Rochester Medical Center. During development, complex genetic programs specify and assemble...technological gap, a trio of recent papers describe the development of CRISPR activation (CRISPRa) tools for neuroscience...recently circumvented by the Yang Lab with the development of a Suntag-p65-HSF1 (SPH) transgenic mouse (...regulates neuronal physiology by promoting the development of neurons and synapses as well as long-term ...

...and gels). As a freshman in college I studied development and evolution of histone genes in Strongylocentrotus... in a tank, and observe the beauty of embryo development in real time. I was already a biology geek, but...that can be studied by providing support "for development of tools, approaches, and infrastructure necessary...juvenile, light microscope with polarizing filter. Development is direct in this species, and hatchlings are...

...provide a strong proof of concept for further development. Figure 2: Mechanisms of deaminase-based...editor allows guanine transversions And further development was on its way! All base editors up to this point...Still, it opened a new avenue for base editor development going forward. Figure 3: Mechanism of ...Shi, L., Yao, X., Zhou, Y., & Yang, H. (2024). Development of deaminase-free T-to-S base editor and C-to-G...

...of our QC process. Automation and continuous development of in-house software has been crucial for us ...microplates, and thanks to our dedicated product and development teams, frequent updates allowed us to scale our...and well-supported, so we could focus on our development instead of building the entire ecosystem Proven...computing resources. Now, we could iterate our development and testing cycle faster due to the ease of jumping...

...them in numerous fields including research and development, diagnostics, drug discovery, and food safety...chemiluminescent substrates are available. Labs with limited equipment often opt for the chromogenic substrates since...chemiluminescent methods that require specialized equipment. Chromogenic methods are not as sensitive, however...followed by conjugated secondary antibodies. Assay development, however, can be challenging since scientists...