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... you only look at 2 or 3 pairwise comparisons. Similar to family-wise error, is the false discovery rate... to reduce false positive rates and control for large numbers of comparisons. The Bonferroni does this...arranging all calculated p values from smallest to largest and ranking them (1 being the smallest value). ...calculates the cut off for significance by finding the largest p value where its rank divided by the total number...positives/negatives, but they all generally yield a similar result and are appropriate to use if all sample...

... Read the molecular biology reference Find plasmids for your research Brush up on molecular biology protocols...as pure as for other uses.   Cloning grade DNA Molecular cloning includes a set of techniques that are ...consequence, the preparations for this technique must be larger scale, to allow the extraction of enough plasmid...

...Toolbox: Free Online Molecular Biology Tools by Beth Kenkel There's a lot of free molecular biology tools out...post. 8. Chromoproteins: Colorful Proteins For Molecular Biology Experiments by Jennifer Tsang Chromoproteins...generate color! They've been adapted for many molecular biology methods such as allelic exchange, FRET...

...limited to particular model organisms or cell types. “This tool is really flexible and modular,” Konermann... vitro by a factor of 10 to 20. A flexible and modular optogenetics tool The researchers also showed just...novel mode of optogenetic control of endogenous cellular processes." The LITE system can now be applied...

...food on special occasions. However, employees regularly bring in baked goods and we have a few unique ...During Hack Days, teams at Addgene will forgo their regular To-Do lists (other than emergency items) and focus...United States, I look forward to gathering around a large table for a meal with my family. I am thankful for...things, and one is that I get to gather around a large table to eat with my Addgene family every day. Do...

...transformants. Addgene distributes several ready-to-use, modular plasmids, combining fluorescent tags, epitope tags.... John Pringle and Jürg Bähler have deposited a large collection of plasmids for genome modification in...at UNC Chapel Hill. Bähler et al.(2) describe a modular collection of plasmids for a wide variety of genome... to the collections featured above, many other modular yeast tagging systems have been developed in the...

...alpha-1a adrenergic receptor; nLightG contains circularly permuted green fluorescent protein (GFP), and...green fluorescent proteins. nLightR did perform similarly to GRABNE, and having both colors allows for increased...AR. Selectivity Norepinephrine and dopamine are similar molecules, and cross-reactivity is a very common...continues to work on further improvements. In particular, they’re focused on generating variants with ...

...can help reduce off-target activity. Deleting a large region of the genome by removing the sequence between...Transcript Multiplexing Plasmids: These plasmids are similar to the Csy4 polycistronic system described above...Addgene. 4. Albers, Joachim, et al. “A versatile modular vector system for rapid combinatorial mammalian... genome editing in monocot and dicot plants.” Molecular Plant 8(8) (2015): 1274-1284. PubMed PMID: 25917172.... 11. Cress, Brady F., et al. “CRISPathBrick: Modular Combinatorial Assembly of Type II-A CRISPR Arrays...

...control over neuronal activity. While they serve similar purposes, both techniques offer researchers different...have faster off kinetics and allow neurons to repolarize faster.  Chemogenetics does not offer the same...targeted to specific tissues, cell types or even subcellular regions of a neuron. Optogenetic approaches excel...with light accessible brains, such as zebrafish larvae. Mouse studies, however, require a permanent intracranial...

...researchers and ready access to stably archived large-scale datasets by computational biologists. ...genome-wide datasets, which are often obscured in large supplementary data files, BioGRID ORCS makes it ... interest. In addition, users interested in a particular disease, cell type or drug treatment can browse...used to search the entire CRISPR database for particular screens of interest.   Figure 3: Each ...