...specificity, or retrograde transport in neurons. (b) Genetic cargo can be customized to control transgene expression...
Capsid
Published Tropism
Model Organism
Mouse Strain-Specific Tropism?
Reference
AAV-...and astrocytes
Mice
No (LY6C1)
Hanlon et al., 2019
AAV-BI-28
CNS: neurons, astrocytes, oligodendrocytes...-Specific Tropism?" column. For a complete list of mice strains with LY6A-dependent tropism, see S3 table...derived from AAV9 using iTransduce, shows tropism toward astrocytes and neurons, with greatly increased efficacy... appears to show a broader tropism with a potential bias toward astrocytes (Chuapoco et al., 2023). Additionally...systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nature Communications...