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We narrowed to 117 results for: atm

Showing: 21 - 40 of 117 results
  1. CRISPR 101: Drug discovery and CRISPR

    Type
    Blog Post
    Published
    May 4, 2023, 1 p.m.
    ...requires understanding the disease genetics and the “treatment” usually requires drugs. While we often think ...combinatorial drugs on for effectiveness prior to patient treatment. Target validation When a target is known and ...
  2. History of CRISPR Cas - A tale of survival and evolution

    Type
    Blog Post
    Published
    Nov. 25, 2013, 10:12 p.m.
    ...Wikipedia, accessed 25 November 2013. Author: James Atmos (2). Many CRISPR/Cas moieties carry out these...Wikipedia, accessed 25 November 2013. Author: James Atmos. http://en.wikipedia.org/wiki/File:Crispr.png ...
  3. Meet the New Addgene Board Members!

    Type
    Blog Post
    Published
    April 28, 2020, 1:14 p.m.
    ...Ultragenyx’s goal is to develop novel products for the treatment of rare and ultra-rare diseases. “Today, I am ...of more than 1 million cancer cells under drug treatment.” Stegmeier especially finds the value in the ...
  4. Using CRISPR/Cas9 to Edit Disease Out of the Genome

    Type
    Blog Post
    Published
    June 23, 2022, 1:15 p.m.
    ... to treat human genetic diseases, and several treatments are currently being tested in clinical trials...The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Alzheimer’s Disease.” Journal of ...
  5. Predicting Adverse Reactions to Monoclonal Antibody Drugs

    Type
    Blog Post
    Published
    Feb. 13, 2024, 2:15 p.m.
    ...the risk of an adverse immune reaction to the treatment. These responses vary depending on the person....Development of therapeutic antibodies for the treatment of diseases. J Biomed Sci 27, 1 (2020). https:...
  6. Plasmids 101: Screens vs. Selections

    Type
    Blog Post
    Published
    Nov. 10, 2022, 2:15 p.m.
    ...manipulation are genetic knockout mutations and treatment with small molecules/drugs. With the advent of...mutation to assess how patients may respond to drug treatment. Another example is using a mouse model of a particular...
  7. Adeno Associated Virus (AAV) for Cell and Gene Therapy

    Type
    Blog Post
    Published
    Nov. 7, 2017, 1:59 p.m.
    ... replacing the gene. A notable example is the treatment of Severe Combined Immune Deficiency disease (...in vision over a period of 1 to 3 years – the treatment appears to be both safe and effective. Challenges...
  8. No Llamas Required - Synthetic Nanobodies Against Membrane Proteins

    Type
    Blog Post
    Published
    June 18, 2020, 1:15 p.m.
    ...lot of press for being a promising approach for treatment or prophylaxis of COVID-19. Researchers identified...research, this protocol holds promise for developing treatments for other diseases or for studying other membrane-bound...
  9. Uncovering Ancestral Bias in CRISPR Research

    Type
    Blog Post
    Published
    Nov. 29, 2022, 2:15 p.m.
    ...Cancer Dependency Map cancer cell lines (left). Heatmap indicating the breakdown of ancestry associated...Cas machinery where to cut.      Fig. 2: Heatmap indicating loci where SNPs reside on sgRNA target...
  10. Deep Dive: Fixing and Permeabilizing for Immunofluorescence

    Type
    Blog Post
    Published
    Aug. 30, 2022, 1:15 p.m.
    ...fix and permeabilize in one step, then methanol treatment could be an effective strategy. (This article ... Chen JW, et al (1985) Postfixation detergent treatment for immunofluorescence suppresses localization...
  11. Deciphering the Mysteries of Behavior with Viral Vectors

    Type
    Blog Post
    Published
    Sept. 17, 2019, 12:40 p.m.
    ... 1970s to test the efficacy of antidepressant treatment in rodents. In this test, an animal is placed ...deep brain stimulation to emulate optogenetic treatment of synaptic pathology." Science 347.6222 (2015...
  12. Targeting HIV-1 with CRISPR: Shock and Kill or Cut it Out?

    Type
    Blog Post
    Published
    May 10, 2016, 2:30 p.m.
    ... viral levels will soon skyrocket back to pre-treatment levels due to the viral reservoirs located in ...cell lines, as well as a latent microglial line, treatment with CRISPR/Cas9 SAM increased the percentage ...
  13. Deep Dive: Statistical Tests (Comparisons)

    Type
    Blog Post
    Published
    March 7, 2023, 2:15 p.m.
    ...same subject or population - before and after a treatment, for example - should be analyzed with a paired...arising from different subjects or populations (a treatment group vs. a control group), on the other hand,...
Showing: 21 - 40 of 117 results