We narrowed to 362 results for: pme

...sing with delight? From developmental biology to developing a career Developmental biology caught me early...Science on developmental neurobiology and plant sciences, viewed through the lens of development, cell, and... with information. I am fascinated with how developmental programs unfold, absorbing the stochasticity...followed that avenue with projects studying developmentally programmed regulation of DNA replication and...

...which I use to study gene regulation during developmental processes, CRISPR/Cas9 allows us to delete sequences...selective marker to remain in the edited animal. Development of CRISPR/Cas9 editing strategies in C. elegans...cases, injection of Cre is required, however the development of the self-excising cassette (Dickinson et al..., such as GFP (Paix et al., 2014). A further development of this approach reported in 2017 uses the direct...co-conversion markers. Expanding beyond Cas9 Since the development of CRISPR/Cas9 editing methods, other Cas proteins...genome. Toolkits for editing in C. elegans The development of toolkits such as the SapTrap CRISPR/Cas Toolkit...transformative innovation for our community. Developments in mammalian and yeast cells using modified ...

...interested in learning a new skill, getting access to equipment you don’t have, or maybe both, a visiting scientist...typically). A visiting scientist is distinct from equipment sharing or a collaboration – it requires re-location...Alternatively, the host institute may have a piece of equipment that is custom-built, hard to find, or inaccessible...often have some form of built-in professional development. These programs are often great choices if they...visitation if they have specialized skills and equipment! Preparing for your visit   Design and communicate...

...applications Vaccine development Attenuated and inactivated viruses pioneered vaccine development well over a ... lot, but viruses have stuck around. Vaccine development is moving away from delivery of the actual virus...response even after a single dose. Vaccine development strategies. Image courtesy of Gorry et. al, 2007..., et al. The use of viral vectors in vaccine development. Vaccines. 7, 75 (2022). DOI: https://doi.org...

...and holding one another accountable for their development plans. They all found the support of the group...ongoing support, advice and accountability for development goals. These programs also serve as a great first-time...skills and to hold them accountable for their development plans. However, they find it awkward to ask someone...mentees. Because the participants are at a similar development stage, they have a lot to learn from each other...Experiment with the process. Have each person write a Development Plan. Set concrete goals with input from the ...

...writing, clinical, regulatory, product development, business development, consulting, policy, big data and ...presented may not reflect the most current legal developments.  Further, this post may contain technical inaccuracies...necessary and often overlooked part of career development for foreign national researchers and entrepreneurs... Careers is a life science search and career development firm focused on connecting innovative, entrepreneurial...project management, alliance management, business development, finance, and operations. To learn more, visit...

...counter movement by the public to access basic equipment and to become involved in developing tools and... skills to help do science on the cheap using equipment that would otherwise be discarded. For instance...learned to be resourceful and to repurpose old equipment for new uses. We’ll probably never use the Illumina...optics and fluidics platform it contains. Biotech equipment becomes obsolete amazingly fast, but with a wide...diverse array of capabilities. So don’t throw old equipment away until you ask your local makerspace if they...

...fun science events for adults and professional development opportunities for researchers interested in connecting...Find people who will support your professional development I had a wonderfully supportive mentor and graduate...there were multiple avenues for professional development including workshops and networking events. I ...speakers and participants for our professional development programs. I also reach out to my network to find... professional development...

...particularly related to the neurosciences.  These developments in microscopy coupled with techniques that make...anterior, P= posterior, D= dorsal, V= ventral Developments in light sheet fluorescence microscopy Modern...Murray's clear (11) was mostly used to study the development of vertebrate embryos.  The first 3D reconstructions...Pubmed. J. Huisken, and D.Y.R. Stainier. (2009). Development, 136, 1963–1975. Pubmed. J. Huisken, J. Swoger...J.A Dent, A.G. Polson, M.W. Klymkowsky. (1989) Development, 105.61-74. Pubmed. J. Sharpe, U. Ahlgren, P....

... to invest too much of our internal software development resources into it. At the same time, this project...within my department where we shared materials and equipment between labs. Later I worked with people outside...specific projects where you share methods and equipment between lab groups and departments. You don’t ...-to-date on your collaborators’ professional developments without directly contacting them. One great ...for jobs focusing on: Science Policy, Business Development, Administration and Intellectual Property (Sinche...

...gene, Rett Syndrome is a rare, progressive, neurodevelopmental genetic disorder that affects primarily girls... girls. After a period of seemingly normal development through ages 6 to 18 months, individuals with Rett...suggesting that MECP2 is also essential after development (McGraw et al., 2011). Adrian Bird’s 2007 landmark...gene therapy candidates advanced into clinical development programs in biopharma. AveXis, co-founded by ...Delivery. Molecular Therapy - Methods & Clinical Development 5:106–115 . https://doi.org/10.1016/j.omtm.2017.04.006...

...biological research, medical therapy, and even drug development (Grimm & Lavis, 2022). With the wide breadth ...the filter cubes and filtering settings of the equipment. Systematic evaluation of commercially available...Advancements in dye chemistry have led to the development of more stable, brighter, and specific dyes, ...J., Raverdeau, M., & Voorheis, H. P. (2016). Development of a quantitative fluorescence-based ligand-binding... R., Bousfield, D., & Demokritou, P. (2019). Development & characterization of fluorescently tagged nanocellulose...

...tumors and cancer. The immune response to the development of tumors is a complicated and dynamic phenomenon... Equilibrium - In a process analogous to the development of drug resistance in bacteria, the tumor cells... onset of cancer. Similar patterns of cancer development are observed in autoimmune disorders. Chronic...autoimmune disorders is also known to precede cancer development, for example, inflammatory bowel disease is associated...in the various types of cancer will fuel the development of immunotherapeutics. There are still many important...

...pathways that are worth investigating for drug development. Due to the difficulty of drugging some targets...occur, such as in the context of a specific developmental phase. As CRISPR keeps advancing, so will drug..., et al., Cornerstones of CRISPR-Cas in drug development and therapy. Nat Rev Drug Discov (2017) 16(2)...CRISPR Plasmids and Resources CRISPR History and Development for Genome Engineering    ...

...on setting SMART goals using a Development Plan template. A Development Plan or mentoring journal will...perhaps, asked someone to support your career development as your mentor. How do you make the most of this... reap rewards in the form of reaching career development goals. Check out Joanne's Reddit AMA Add a ...

...programs provide support for academic career development, it's often left to students to identify and ...career-planning platform called the Individual Development Plan (IDP) and uses it to match qualified scientists...approaches for scientific tool and technique development. However, careers outside of the lab highlight...career planning tools such as the Individual Development Plan to generate a list of potential professions...

...Koeris, co-founder and current VP of Business Development & Operations of Sample6, for advice on how to...months in graduate school focusing on concept development and participating in business competitions. When... COO, then moved on to become VP of Business Development & Operations. Starting a biotech company ...money. Moreover, many universities throw out old equipment that still works. “We use functional spectrometers...

... and metabolic reprograming influence tumors development? Being pathological active regions, microenvironments...Witkiewicz et al., 2009) which contribute to the development and spread of cancer cells. Besides these stromal...CAFs are altered fibroblasts and promote the development and metastasis of tumors through inciting inflammation...tumor may seem to take center stage in cancer development, the microenvironment backstage play just as ...

... involved in a broad range of reproductive, developmental, metabolic, and immune response programs. NRs... so would not have been possible without the development of a vast number expression and reporter plasmids...exchange of these vectors between laboratories. The development of the transient transfection platform for assaying...transcriptional activity, for example, was a key development in the functional characterization of NRs and...

...elements were the starting point towards the development of the first cytosine base editors from Alexis... base editing scope and efficiency Since the development of BE3, many research groups have made improvements...guanine (Thuronyi et al., 2019). Following the development of adenine base editors (discussed next!), RNA...constrained by PAM availability in the genome. So the development of near-PAMless Cas9 variants significantly expands...CRISPR 101: RNA Editing with Cas13. Finally, the development of prime editing, which uses a different mechanism...