A new platform for fast functional characterization of potentially cancerous mutations
Type
Blog Post
Published
May 7, 2019, 12:39 p.m.
...more about their work, and how these plasmids can help cancer researchers studying an assortment of genes...population, as mutations with strong phenotypic effects can mask weaker ones.
Thus, the need for a faster and...phenotypic effect in a different system.
These plasmids can also help scientists understand how a given gene ... genetic perturbations that may play significant roles in cancer pathogenesis.
Their work culminated ... from The Cancer Genome Atlas (TCGA), a catalog of genetic mutations responsible for cancer from genomics...interventions for cancer.
This screening platform is an incredible boost to the cancer research community...functional annotation of somatic mutations in cancer." Cancer Cell 33.3 (2018): 450-462. PubMed PMID: 29533785...