We narrowed to 904 results for: CAN

...mentoring program at your organization, contact me! I can provide a step-by-step, how-to guide to get one started...same time Broadens the network of the participants Can be a lot of fun! Form your own peer mentoring group...interested and willing to commit to the group. The group can be one gender and career stage (e.g. all women, all... mixed for one or both of these criteria. If you can, include people from different labs, departments ... from peer groups meeting at both the Fox Chase Cancer Center and Brandeis University. 5 easy steps to...meet regularly no matter what, even if one person can’t make it. One of the biggest group mentoring predictors...

...interested in engaging with us on social media, you can find us on Bluesky: @addgene.bsky.social; or @addgene...associated with an official Addgene account. You can reach out to us directly via email at [email protected]... suggestions in the comments.  X has moved significantly away from the functionality and features that...this reason, our timeline has accelerated. We significantly reduced posting on November 20, 2023, and as...

... with the other 11 presents!)  Can't get enough of CRISPR? Neither can we! Subscribe below to get updates...CRISPR in 2021 and useful resources, fear not! You can find all of them here.  On the first day of CRISPR...

...) are flanked by unique restriction sites so you can swap sequences effortlessly.  We built these plasmids...plasmids for flexibility and speed, so you can design, test, and innovate faster than ever. Plus, we've...fused to a shortened R2Tocc transposon protein, and can "retarget" the transposon to new loci in the genome...recruitment and nicking, producing STITCHR. STITCHR can make a wide variety of genomic edits — single-base... proteins with biotin. The biotinylated proteins can then be isolated and identified with tools like mass...gene expression to specific cell types in the brain can be a challenging — but critical — factor for successful...the IPI Glypican Collection here! Figure 3: General glypican domain structure. Glypicans are proteoglycans...

...published concurrently in Science have shown CRISPR can treat a genetic disease in a postnatal mouse model...another approach. Since shorter forms of dystrophin can still be functional, exon skipping is a good option...culture, but Ran et al. have shown that CRISPR and AAV can be used together for postnatal genome editing in ...strategies for Duchenne muscular dystrophy. gRNAs can be designed to flank a single or multiple exons that...’d like to treat with CRISPR. As seen above, DMD can be treated with “one-size-fits-most” NHEJ-mediated...DMD. If the safety and efficacy of this approach can be optimized, DMD could become one of the first diseases...science.aae0169 2. Long C, Amoasii L, Mireault AA, McAnally JR, Li H, Sanchez-Ortiz E, Bhattacharyya S, Shelton...

... our mindsets and needs can change. Having been at Addgene for a month, I can say with certainty that ...options is being an overthinker. Being an overthinker can make me scared of taking risks, afraid of leaping... I introduced the team to a new design program, Canva, and I was able to create cute and on-brand templates...

...incorporates a bioluminescence protein into the chitin that can be activated only by a specific frequency. Once activated...eye, at regular intervals. This innovation system can help fly labs everywhere find and re-contain any ...well, annoy. Fly-related Issues in the Lab A significant drawback of working with fruit flies is their...

...genome that can cause disruption of functional genes at the site of insertion and which can potentially...cells that are otherwise difficult to obtain. These can then be used to perform cell therapy and to model...is sold at $11,000 at ThermoFisher Scientific and can be used for only 6-8 reprogramming reactions. Another...terms of hiPSC colonies, nearly 16 hiPSC colonies can now be obtained from just 1 ml of peripheral blood...

...communities have a little more leeway in what they can name a gene and many of the interesting ones come...also have many plasmids in our repository that you can use to study these genes! Groucho, a transcriptional...Addgene has several plasmids that contain SHH, you can find them all here! The most popular SHH plasmid ...Sleeping Beauty is a synthetic transposon system that can be used to insert specific pieces of DNA into vertebrate... resurrecting this transposon system? Scientists can use Sleeping Beauty transposons as a non-viral system...deposited by the Shivdasani Lab from the Dana Farber Cancer Institute! Sonic Hedgehog, an important regulator...

...requirements expand the number of genomic sites that can be targeted with TnpB, offering access to regions... TnpB is a much smaller genome editing tool that can be efficiently packaged into viral vectors. Even .... In our recent study, we demonstrated that TnpB can also function as an efficient gene activator when...et al., 2024). Additionally, we showed that TnpB can be used to simultaneously target multiple genes, ...efficiency of guides are currently unavailable, you can use TEEP — a tool based on animal data. Step 2...