We narrowed to 904 results for: CAN

...healthy donor cells can be delivered immediately, saving precious time. CRISPR can aid in editing these...There can be no doubt that CRISPR/Cas9 technology has been a breakthrough for the genome-editing field...delivery directly to the patient. Patient-derived cells can alternatively be harvested, edited ex vivo, and then...Therapies Cancer and CAR-T therapy The FDA has already approved CAR-T immunotherapy for cancer treatment...therapies that are currently approved or have made significant progress in clinical trials.     Figure...graft vs. host) as well as the introduction of the cancer-fighting component, CAR. Clinical trials are underway... CRISPR’s capacity for both classes of edits in cancer therapy. Blood disorders Two blood disorders are...

...understand the power of a physical model. Until then, you can only wonder what I am talking about. How do researchers...   Seeing is believing. And in that sense, models can be both useful, and dangerous. Subscribe to CRISPR...we have when we jump into a new modeling project can be a dangerous thing. Fortunately, Jacob was able...physical model is an effective teaching tool. You can read about Jacob’s initial reaction to this model...flexibility that the Cas9 protein must have in order to scan along the double-stranded DNA, recognize a PAM sequence...

...Pulse Stimulator, which can control output of several lasers simultaneously, can be used to set the laser...to use to determine the ideal excitation). Lasers can be purchased through Laserglow, which caters to optogenetics.... However, an important caveat is that one laser can stimulate only a single animal during the course ...cement (a similar procedure as implanting a guide cannula). A fiber optic patch cable is then connected from...portion of optogenetics (though it does require a significant amount of equipment, most of which is relatively...point; the fiber optics need to be polished to significant smoothness to prevent drastic loss of efficiency...stimulation, the rate of movement of the animal significantly increases. Before you get your experiment started...

...is, we’re not only sharing them with you, but you can share them with your coworkers, labmates, and friends...more than plasmids these days. via GIPHY   You can see for yourself at giphy.com/addgene. But that’s... interest).   Blugene is so excited they can’t stop dancing! via GIPHY   Don’t forget to check...

...last year less than 30% of applicants received sponsorship) then he or she can start working in October ...this case.  You can still assist your PI in the peer review process, but remember you cannot use it as documentary...responsibilities during their careers - being aware of this can help take the pressure off having to find the perfect...process or quota like industry, these organizations can be a good choice for individuals needing sponsorship...organization – this is not referring to one that you can pay for, but one that you are invited to join (selected...attractive option.    Your Expert Letters of support can mean that your case gets approved, denied or a Request...who has cited your work. Immediate steps that you can take to prepare for the green card process Update...

... for these methods can be found on Addgene’s stem cell page. On this page, you can also find a table with...vitro is known as reprogramming [1]. The process can be divided into two stages: Dedifferentiation - ...cell type of choice. The four reprogramming factors can be delivered and expressed in multiple somatic cells... of somatic cells. The goal is to use cells that can be easily isolated from donors. Apart from fibroblasts...Otic hair cells [31] Neurons [32, 33, 34] You can find a variety of plasmids for differentiation here...the Stem Cell Field Learn how lentiviral vectors can be used for gene delivery Resources on Addgene.org...pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A, 2012....

...research to explore a variety of phenomena, and so too can it be used to teach a variety of science concepts...deeper understanding of scientific concepts than can be gained from lectures alone. Using plants as an...Resources on the Addgene Blog Learn how BioBuilder can bring Synthetic Biology into the classroom Engineering...Arabidopsis in the classroom With funding from the American Society of Plant Biologists and support from the...

...IgnaviCas9 here! What can you do with IgnaviCas9? Why would a thermostable Cas9 be useful? It can enable applications...nuclease activity is desired and time or protocol steps can be saved by flexibly deploying IgnaviCas9 without...

... fire at a certain frequency, and this frequency can indicate behavioral state, for example, if someone...quantitation. The advantage of this method is that it can be performed in a live awake animal by surgical implantation...offers immediate measurements in a live animal that can be correlated to behavior, the technique is relatively...

...buffeted by wind and waves and sometimes wonder if we can take another blow. Back in March, we never expected... when we need as much open science sharing as we can get. The effects of Addgene’s brief shut-down...excellence through whatever lies ahead this year. We can see signs of the storm passing. We’ve recently piloted...