We narrowed to 892 results for: CAN

1. The Power Behind NGS Plasmid Validation: seqWell

   Type

   Blog Post

   Published

   April 19, 2017, 3:25 p.m.

   ...challenges in NGS by developing technologies that can help unlock the potential of modern sequencing instruments...because the yield or quality of individual libraries can be influenced by the quantity or quality of input...normalization steps, measured in time and consumables, can be daunting for large numbers of samples. As mentioned...

2. The Crispr Babies Saga Shows the Need for Action, Not More Delays

   Type

   Blog Post

   Published

   Dec. 20, 2018, 1:15 p.m.

   ...things we can navel-gaze over from the last couple of weeks, including whether or not scientists can recognize...model of public involvement, research, and consensus can happen. We just have to look to the United Kingdom...

3. Optimizing Donor DNA for Enhanced CRISPR Genome Editing

   Type

   Blog Post

   Published

   March 24, 2016, 2:30 p.m.

   ...repaired by homology directed repair (HDR) pathways can modify the sequence of a gene (thus altering its ...revealed some of the biophysical parameters that can influence the HDR/NHEJ decision. Our conclusions ... the sequences of our validated editing reagents can be found on our plasmid pages. We encourage any labs...

4. Don’t Wait To Launch Your Health Science Startup

   Type

   Blog Post

   Published

   Aug. 25, 2015, 2:30 p.m.

   ...functional prototype to gain any real traction.  This can carry a heavy price tag, especially if you're working...focused on empowering early-stage scientists. You can think of miLab as a sort of talent agency for scientists... of the potential contacts your personal network can offer, you are really on your own to build a strategic...majority of these meetings acted as a platform for significant company advancement. Be relentless The world ...

5. Another Pathway into Cells: iTOP

   Type

   Blog Post

   Published

   June 23, 2015, 8:37 p.m.

   ...discovered in the HIV protein Tat. Although CPP fusions can translocate a cell membrane, the presence of the ... took up both Cas9 protein and a gRNA (yes, iTOP can also be used for RNA transduction) targeting a gene...Na+ hypertonicity are key elements of iTOP. iTOP can be used to transduce Cas9 and a gRNA, which subsequently...

6. Resume Writing for Non-academic Science Careers

   Type

   Blog Post

   Published

   Dec. 18, 2014, 4:06 p.m.

   ...potential employer that you are the right candidate for the job. How can you incorporate the skills developed... school into your resume? How can you stand out among all the candidates applying for the position?   ... a Communications Coordinator. Wondering how you can develop more transferable skills? See Developing ...surprised to learn how often I see resumes from good candidates that I almost missed because I had to “dig” hard...topic will give you some advantage over other candidates. Write about your transferable skills Some of...

7. Advice for Moving Into Sales After Your Science Postdoc

   Type

   Blog Post

   Published

   Aug. 21, 2014, 3:15 p.m.

   ...careers outside of academia, sales and marketing can be great places to start. Depending on what type ...set up an ELISA kit company on whose website you can find some great information on ELISA troubleshooting...troubleshooting, ELISA kits and cell death assays. You can find Seán on twitter @Macfhearraigh.    Read more posts...background of the applicant. However, although this position did look for an academic candidate, I knew they... look for work outside of academia, a job as a ‘Cancer Marketing Coordinator’ came up at Abcam. Unlike...specifically looked for a researcher with 3 years+ of cancer research experience, a PhD or a Master’s degree...they would look for a candidate with extra experience or a marketing interest that would be able to apply...

8. CRISPR 101: RNA Editing with Cas13

   Type

   Blog Post

   Published

   July 31, 2020, 12:30 p.m.

   ...these tools were developed and potential ways you can use it in your research. RNA editing advantages RNA...optimize cytidine deaminase activity. While RESCUE can perform C-to-U edits, the authors note that it retains...expands the RNA editing toolkit and sequences that can be edited.   As discussed above, the ability to edit...therapeutic uses We are also curious if REPAIR and RESCUE can function in a multiplexed manner to edit multiple...HNH domains responsible for DNA cleavage, so they cannot directly edit the genome. A Cas13-based RNA editing...

9. Multiplexed Capture of Promoter-enhancer 3D Chromatin Structures Using CRISPR

   Type

   Blog Post

   Published

   July 2, 2020, 12:40 p.m.

   ...sequences that, when bound by transcription factors, can increase a gene’s transcription. Sometimes enhancers.... Cross-links are reversed so that DNA fragments can be detected by PCR or deep sequencing. A drawback... interactions networks as a social network. They can tell you things like which enhancers are interacting... accessibility, and epigenetic modifications, we can start to build a timeline of events that surround...

10. AAVs in Retinal Gene Therapy

    Type

    Blog Post

    Published

    July 31, 2018, 12:55 p.m.

    ...ideal target. It is an easily accessible organ that can be monitored non-invasively over time. Importantly...an immune privileged compartment, meaning that it can tolerate the presence of antigens (such as viral ...identified serotype and the one used in Luxturna™, can efficiently transduce various types of retinal neurons... success so far. Luckily for patients, this gene can be targeted to RPE cells using a lentiviral vector...most - which means that a gene larger than 3 kb cannot be delivered using this vector. For example, although...results in preclinical studies some potential candidates for rare to ultra-rare ocular diseases are being... co-founded a non-profit to help push forward candidate therapies for these diseases. Riding on the early...