We narrowed to 904 results for: CAN

...requestors, and supported by our repository. You can enjoy these stories, and other 20th anniversary celebrations... our diverse community, which I truly believe we can only serve through active conversation and collaboration...

...the human, pig, or zebrafish genome, this system can be used in these organisms. Read the paper in bioRxiv... but with the addition of 4-hydroxytamoxifen, it can move to the nucleus for activity. They also developed...for cancer research The Sidi Chen lab recently published two CRISPR knockout libraries for cancer research...inhibition library CRISPR knockout libraries for cancer research Creating knock-ins with GeneWeld vectors...

...through Science Careers’ myIDP tool. Using myIDP, you can identify suitable careers based on your current interests...and skillset. With this information in hand, you can then formulate a plan to further develop your transferable...

...me pursue this, let me make a slight change so I can have flexibility and be up to date with the current... It is incredibly helpful to me to know that you can make big changes in your career path and still find...done that, my big takeaway has been the impact I can have on an organization beyond my job description...

...screens in cancer cell lines, looking to uncover genetic dependencies of individual tumors, which can lead ...prevent Cas9 from cutting, both of which can introduce significant bias into the results. But the reference...genome – even single mismatches within a CRISPR guide can prevent the guide from binding to the genome or prevent...major ancestry groups for 994 of the Cancer Dependency Map cancer cell lines (left). Heatmap indicating...methodology, they estimate that the African ancestry-associated cancer dependencies are undercounted by ...development, particularly in cancers that are more common in individuals of African descent.Correcting the ...Broad Institute of MIT and Harvard, Dana-Farber Cancer Institute, and Koch Institute, where an exploration...

...genome is majorly composed of three proteins that can be easily modified in order to facilitate its entry...vectors As compared to other viral vectors, AdVs can provide a large transgene packaging capacity. For... DNA Adenoviral CRISPR/Cas9 genome editing tools can also be used to deliver Cas9 and DNA templates in...used so far) or for cancer gene therapy such as nonalcoholic steatohepatitis cancer. In deficiencies of...particular cancer. That’s exactly what the lab of Andrea Ventura at the Memorial Sloan Kettering Cancer Center... 2012). These features make AdV an attractive candidate for in vivo delivery of advanced genome editing...Center did to create a model of Eml4–Alk-driven lung cancer (Maddalo et al., 2014). These tools are available...

...their own CRISPR arrays. On the other hand, viruses can evolve to evade CRISPR by mutating these sequences...target in order to cut DNA, whereas some mismatches can be tolerated outside this region. Conclusion Ready...

.... Plasmids with wild-type Cas13a (formerly C2c2) can mediate targeted RNA knockdown, which leads to unique...cells with CRISPR? I certainly didn’t, but now we can with Cas13b/ADAR constructs from the REPAIR (RNA ...

...little-known disease. You can find more information about the disease on the Meothelioma Cancer Alliance Website...lymphoma research or the many different ways you can improve your heart health. These are amazing advances...tumor samples that they have used to identify candidate genes as drivers of peritoneal mesothelioma tumorigenesis... to knockout, knockdown, or overexpress these candidates in a panel of ~30 patient derived peritoneal ...These experiments will serve to validate these candidate genes and allow Nabavi and colleagues to prioritize...

...interest. Auxotrophy Besides antibiotic selection, you can select for a successful uptake of your DNA of interest...contain constructs that have lost the sacB gene. SacB can be used similarly to CcdB. For example, in the gene...