We narrowed to 904 results for: CAN

... genomic loci in live cells. While other systems can be used to label loci, such as fluorescence in situ...potential solution is SunTag, a synthetic scaffold that can be used to recruit multiple protein molecules (and...stimuli. It could also have major applications to cancer, for example, the visualization of chromosomal ...

... conventional PCR. Biallelically disrupted cells can be easily identified. Even in the case of clones ...of many available strategies by which biologists can imagine, create, and examine novel genetic configurations...post was contributed by Daniel Bauer and Matthew Canver of Boston Children’s Hospital and Harvard Medical...deletions in mammalian cell lines. Below Bauer and Canver discuss the motivations behind this research.   ... more at his webpage, bauerlab.org.     Matthew Canver is an MD/PhD student at Harvard Medical School ...Science 2013 Oct 11;342(6155):253-257. PubMed. 3. Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda ...

...weak, government support is “feckless”.  So what can be done?  He charged the postdocs to “Grab ahold ...destinies” and also suggested some concrete actions that can be taken now to solve some of the more “tractable...Workforce, Metrics and Incentives and Funding.  I can’t wait to see what solutions these talented postdocs...science to be happy so the beginnings of solutions can’t come too soon.  Watch the Future of Research Website...

...no doubt that companies are swarming to see what can be done with this technology to help patients. Dr... me, I continue to be amazed at how cool biology can be and how much we have yet to learn. As Dr. Mello... cure sickle cell anemia in stem cells but this can’t be used in people until we learn more about safety...

...infection first of Cas9, then with the sgRNAs, and can result in a higher titer due to the smaller size ...application offer proof-of-principle that CRISPR-Cas9 can be used to target any sequence in the genome. Tips... identify genes essential for cell viability in cancer and pluripotent stem cells. In a melanoma model...in search of genes involved in resistance to the cancer drug vemurafenib. Enriched libraries for select...

... T-Sapphire, EGFP, or mScarlet reporters, so you can choose a color compatible with the other tools in... for lung cells via airway administration. AAV11 can transduce neurons for retrograde labeling, making...connections By Emily P. Bentley While several viral tools can perform neuronal tracing, anterograde tracing poses... the impacts of other cancer mutations and non-genetic diversity in human cancer stem cells. Find the ...biosensor for cAMP dynamics. The mGold2 variants significantly enhanced photostability — 25-fold over mVenus...(STRACK) to study stem cell differentiation and cancer fates (Singh et al., 2025). Key to this method ...for AAV production, purification, and titration. Can't wait? Browse our In-Stock AAV inventory or use our...

...with a flexible linker where a protein of interest can be inserted. B) Protein expression and labeling procedure...voltage indicator (GEVI) than previous versions. ASAP5 can be imaged using one- or two-photon microscopy to ...Altogether, if you want a negative-going GEVI that can be used in different illumination regimes with fast...with non-neurodegenerative diseases (Diabetes & cancer). Image adapted from Wu and Wang 2024 under a CC-BY...

...ve ever had an MRI, you know that magnetic fields can pass right through our tissues unimpeded. Andrew ...engineering approaches and that magnetosensitive tools can be developed from other fluorescent proteins.  Currently...optogenetic tools, they’re optimistic that MagLOV can be similarly adaptable into future magnetogenetic...Maria’s screens of AsLOV2 variants showed some significant gains! After a few more rounds of mutagenesis...ideas and are happy to speculate, they know they can’t answer these questions alone. They readily admit...Confined Persistent Diradical Emitter. Journal of the American Chemical Society, 145(25), 13615–13622. https:...

...confidence and learn to work independently, which can lead to greater success in meeting educational goals...without challenges. Real research is messy, and it can be difficult to give up the control embedded in “... Course-based undergraduate research experiences can make scientific research more inclusive. CBE Life...the training of the mind to think something that cannot be learned from textbooks” (Brian, 1996). But is...citrate synthase and presented their findings at the American Society for Biochemistry and Molecular Biology...

...science outreach, not only can I easily share science with the public, but I can watch and learn from the...dinosaurs every day. They made me happy. Grad school can provide plenty of negativity, so I volunteered at...wonderfully supportive mentor and graduate office. I cannot stress how important they were to my success as...