...typically administered in the lateral tail vein or retro-orbital sinus. IT injections are administered in the...to have enhanced function after intravenous administration, distributing widely throughout the organism... expression, particularly in the liver, when administered intravenously.
To address these limitations,...primarily derived from AAV9, the vectors have to be administered concurrently to minimize the impact of neutralizing...AAV9 and AAV1 serotypes, allowing sequential administration (Chen et al., 2023).
High viral titer
High ...applications. For example, AAV-PHP.eB is typically administered at a total dose between 1 x 1011 and 5 x 1011...find commonly used vector cargo designs and administration doses.
Note: If capsid immunogenicity is a ...