...hands on PGC-1a for studies in your own lab, you’ve come to the right place. Get started with PGC-1 plasmids...findings in a recent issue of Cell demonstrate how PGC-1a1, a transcriptional coactivator induced in skeletal...Mice that are genetically modified to produce extra PGC-1a1 only in their skeletal muscle show resistance...interest in sweets. Further examination of the mck-PGC-1a1 mice found it wasn’t that they were simply immune...brains were protected. Effects of Activation of the PGC-1a1 Pathway Gene expression analysis of the animals...degradation. It turns out that activation of the PGC-1a1 pathway increases skeletal muscle expression ...otherwise lead to depression. And there you have it, mck-PGC-1a1 mice, and those who exercise, show resistance...

...they bind a 6-residue tetracysteine tag (sequence: CCPGCC) that can be inserted into the target protein. ...Range (Å)b Applications CFP   Lumio Green Tc: CCPGCC 50 40-72 Intact Cells Cy3NTAc Poly His  44 35... GFP (fluorescein is similar)   Lumio Red Tc: CCPGCC 48 38-70 Intact Cells Cy3NTAc Poly His  63 50...cells  Cy5NTAc 43 34-62 YFP   Lumio Red Tc: CCPGCC 54 42-78 Intact Cells Cy3NTAc Poly His  65 52...

...plasmid technologies pSV-PGC1 - Ok, it's not actually a technology, but pSV-PGC1 was Addgene's first distributed...