Exploring Applications of the Bioluminescent HiBiT Tag
Type
Blog Post
Published
Oct. 2, 2025, 1:15 p.m.
...explore TP53 biology. They first identified that in a set of patients with gastric cancer (GC), TP53 was ...disordered and structurally complex. The tumor suppressor TP53 (p53) is one example of these difficult-to-study...(Kamio et al., 2025). They designed HiBiT-tagged TP53 constructs, one with an R175H mutation to match ...mutation frequently found in late-onset GC. HiBiT-TP53 expression was detected by blotting with LgBiT, ...expression with a minimally disruptive tag.
Find HiBiT-TP53 Fusion Vector at Addgene!
Following extracellular...Otsuka, M. (2025). Genomic Differences and Distinct TP53 Mutation Site-Linked Chemosensitivity in Early- ...