We narrowed to 4 results for: Tet1

...Researchers showed that TALE-TET1 constructs, which fused a TALEN to the Tet1 demethylase catalytic domain...with BioRender.com. Tet1 demethylase Ronggui Hu’s lab has created pdCas9-Tet1-CD for targeted cytosine...mammalian cells. This plasmid is used with pcDNA3.1-MS2-Tet1-CD to decrease methylation and activate transcription... ready-to-use lentivirus. Figure 2: dCas9-Tet1 demethylates cytosines at promoters and enhancers...increased transcription. Created with BioRender.com. Tet1 initiates cytosine demethylation of DNA. However...oxidation and repair pathways work downstream of Tet1 to restore the DNA after cytosine removal. Recently...system. This system allows for targeted delivery of Tet1 alone, or coupled with DNA oxidation and repair ...

... binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development. eLife...the field: dCas9 fused to the enzymatic domain of TET1 or TET2 (Morita et al. 2016, Xu et al. 2016). But...target site is not as straightforward as expected. TET1 can have many effects independent of dCas9 targeting... RV, Ming G-L, King JR, Song H, Sweatt JD (2013) TET1 Controls CNS 5-Methylcytosine Hydroxylation, Active...demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions. Nat Biotechnol 34, 1060...

... RNA-guided methylcytosine editing by TET1 by co-delivering TET1 and protein factors for linking methylcytosine...., 2019. Fusing epigenetic modifiers such as TET1 with inactive Cas enzymes can alter gene expression...

... by DNMT3A or MQ1, and cytosine demethylation by Tet1. RNA Targeting: This page contains Cas13 constructs...