...intracellular calcium levels within the cell. When levels of Ca2+ are high in the cell, calcineurin dephosphorylates...type (top panels) and cells with high intracellular Ca2+ (bottom panels) equipped with destabilized GFP calcineurin...

.... Furthermore, CRY2clust, when integrated into a Ca2+ -modulating optogenetic system (OptoSTIM1), caused...caused two-fold faster changes in intracellular Ca2+ levels than the original version containing CRY2 without...

...Miyawaki, Atsushi, et al. "Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin...

...emission behavior upon environmental changes (e.g. pH, Ca2+ flux, etc). The most commonly used are GECIs - genetically...

...intracellular conditions, including ion (such as Ca2+) concentrations and pH, using a range of strategies...

... CaMKIIa Gene expression for optogenetics mRNA  Ca2+/calmodulin-dependent protein kinase II promoter ...

...only in pyramidal cells of the hippocampal region CA2 allowed for detailed mapping of the neuronal circuitry...genetic and optogenetic tools reveal novel hippocampal CA2 circuits. Nat Neurosci 17(2), 269–279. PubMed PMID...

...Expanded dynamic range of fluorescent indicators for Ca2+ by circularly permuted yellow fluorescent proteins...

...fluorescent proteins (miRFP670nano and miRFP720) and the Ca2+-sensing domain from Twitch-2B (Matlashov et al. ...

...expression. You must see the movies demonstrating Ca2+ dynamics in cardiomyocytes. Enhanced Nano-Lantern...

...Miyawaki, Atsushi, et al. "Dynamic and quantitative Ca2+ measurements using improved cameleons." Proceedings...