...efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell...easily isolated from donors. Apart from fibroblasts, human keratinocytes from hair pluck, peripheral blood ...types have been successfully differentiated from human iPSCs. Below is a list of some of these cell types...transdifferentiation of glucagon-producing α-cells into insulin-producing β-like-cells [37, 38]. In 1987, Davis... Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 2007. 131(...Induced pluripotent stem cell lines derived from human somatic cells. Science, 2007. 318(5858): p. 1917... et al., Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive...

...diabetes mellitus. Recombinant human proteins that play a role in insulin regulation and diabetes will ...

...physiologically similar to humans than many other model organisms, they are often used to study human diseases. Diseases...counterpart in humans (Liu et al., 2017) . Thus yeast can be used to study the molecular basis of human diseases...They share about 70% of their genes with humans and 85% of human genes associated with a disease have a ...the globe. These organisms share many genes with humans, are easily maintained in the lab, and have short...Diseases in mice show many similar phenotypes to human diseases and have successfully helped researchers...system. The fly has also emerged as an important human disease model with potential for therapeutic drug... estimated that 75% of disease causing genes in humans have a functional homolog in the fly (Pandey and...

...Uhlen M. Large-scale affinity purification of human insulin-like growth factor I from culture medium of ...

...lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells." Nature...