...the eight mice born from Tyr Nanoblade treated zygotes, five had detectable Tyr editing at the phenotypic...proof-of-principle, the team used Nanoblades to disrupt the tyrosinase (Tyr) gene in mouse zygotes, which results in albinism...

...have the option of including a previously-designed tyr gRNA, which causes hypopigmentation, thus marking...

...Some vendors take back their expanded polystyrene (a.k.a. Styrofoam or cooler boxes). We get these boxes...receiving temperature-controlled reagents. Expanded polystyrene will likely end up in a landfill, but at least...with CO2 emissions. NEB takes back expanded polystyrene boxes for free (in the U.S.). Their cooler boxes... 1976! Millipore Sigma takes back expanded polystyrene boxes for free (in the U.S.). After you receive...

...Instead they are detected with tyramide signal amplification. Tyramide signal amplification occurs when...when HRP converts a fluorescently labeled tyramide molecule into a highly reactive radical, which is then...Detection Method Uses Pros Cons Antigens HRP (P) Tyramide signal amplification of HRP Staining cultured...Enzymatic reactions on tissues can be cumbersome Tyramide reagents can be expensive Can only stain with ...

....013 pYtags illuminate RTK signaling Receptor tyrosine kinases (RTKs) are a major class of signaling ...the phosphorylated state of an immunoreceptor tyrosinase-based activation motif (ITAM). By fusing ITAM...enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells. bioRxiv 2022.08.13.503850...

...nanobody fused with a different functional element (tyrosine sulfation consensus sequence, fluorophore, or ...labels electron-rich amino acid side chains (e.g. Tyrosine) with biotin. These biotin-labeled proteins can...

...mRNA using 2a sites. These convert the amino acid tyrosine to betanin, a member of a class of pigments primarily... Fig. 2: (A) Betacyanin is produced from tyrosine by the activity of 3 enzymes and a spontaneous...

...glutamine insertion supF (tyrT)   Suppression of the amber (UAG) stop codon by tyrosine insertion λ-thi-1 ...

...glial fibrillary associated protein (GFAP), or tyrosine-hydroxylase (TH), can limit which cells express...mediated by three partial sequences of the human tyrosine hydroxylase promoter in vivo. Molecular Therapy...

... tools – light-activated receptor tyrosine kinases Receptor tyrosine kinases (RTKs) are a large class ...

...to the office, however. We participate in many styrofoam and plastic recycling programs in the lab as well...

..., Susanna, Tenisha, Thomas, Tony, Tracy, Tyler, Tyrel, Wogenie, and Xuan Additional Resources on the Addgene...

...covalent bond between the cleaved 3′ DNA strand and a tyrosyl residue of topoisomerase I (1). If a 5′ hydroxyl...

...antibodies by applying osmotic pressure and sodium butyrate." Biotechnology and bioengineering 42.5 (1993)...

...-AAV1) GABA sensors Sensing levels of g-Amino butyric acid (GABA) - the primary inhibitory neurotransmitter...

...rearrangements as demonstrated in a mouse model of tyrosinemia, where a pathogenic insertion within the FAH ...

...Cerulean 433nm/ 475nm Lyn-tag (derived from the tyrosine-protein kinase Lyn) Membranes 3 mCherry 587nm...

...amino acids at the center of the protein (Ser65, Tyr66, and Gly67). When first discovered, one of the most...

...editing event. This edit changes the histidine to a tyrosine generating a GFP variant (GFPY66) that has a shifted...

...standby of CRE/flp didn’t work – it turns out these tyrosine recombinases are as bad at integrating as they...