...Neuron 63:27–39. PMID: 19607790 Atasoy D, Sternson SM (2018). Chemogenetic Tools for Causal Cellular and... Lee PH, Atasoy D, Su HH, Looger LL, and Sternson SM (2011). Chemical and genetic engineering of selective..., Hu X, Galvan A, Basu J, Michaelides M, Sternson SM (2019). Ultrapotent chemogenetics for research and... J Biol Chem. 276:1596-6. PMID: 11402033 Sternson SM, Roth BL (2014). Chemogenetic tools to interrogate...

...compatibility and high DNA specificity.. 2018. Hu JH, Miller SM, Geurts MH, Tang W, Chen L, Sun N, Zeina CM, Gao ...knock out target genes in various cell types and organisms, but modifications to various Cas enzymes have...family members inhibit CRISPR by a variety of mechanisms. Some Acr proteins interfere with DNA binding...these principles apply to using CRISPR in other organisms. First, consider the genetic manipulation that...S A . 112(10):3002-7. PMID: 25713381 Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins...

...machinery from a particular organism or group of organisms. Meaning, if a plasmid in intended for use in ...can drive gene expression in a wide variety of organisms, including plants, worms, mice, and even cultured...

...being studied. Examples of published selection mechanisms for lentiviral CRISPR libraries include: resistance...

...can direct the production of virus with various tropisms. Packaging using helper-free packaging cell lines...

...and study certain behavioral responses in model organisms like mice, zebrafish, and Drosophila. These tools...