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pcDNA-f:PGC1 Citations (17)

Originally described in: Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.
Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM Mol Cell 2000 Aug;6(2):307-16.
PubMed Journal

Articles Citing pcDNA-f:PGC1

MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM. J Clin Invest. 2009 Dec;119(12):3817-29. doi: 10.1172/JCI39054. Epub 2009 Nov 16. PubMed
The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells. Alvarez-Guardia D, Palomer X, Coll T, Davidson MM, Chan TO, Feldman AM, Laguna JC, Vázquez-Carrera M. Cardiovasc Res. 2010 Aug 1. 87(3):449-58. PubMed
PGC-1alpha promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply. Klimcakova E, Chenard V, McGuirk S, Germain D, Avizonis D, Muller WJ, St-Pierre J. Cancer Res. 2012 Mar 15;72(6):1538-46. doi: 10.1158/0008-5472.CAN-11-2967. Epub 2012 Jan 19. PubMed
Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells. Antico Arciuch VG, Russo MA, Kang KS, Di Cristofano A. Cancer Res. 2013 Sep 1;73(17):5459-72. doi: 10.1158/0008-5472.CAN-13-1429. Epub 2013 Jun 24. PubMed
SIRT5 is under the control of PGC-1alpha and AMPK and is involved in regulation of mitochondrial energy metabolism. Buler M, Aatsinki SM, Izzi V, Uusimaa J, Hakkola J. FASEB J. 2014 Jul;28(7):3225-37. doi: 10.1096/fj.13-245241. Epub 2014 Mar 31. PubMed
PGC-1alpha provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons. Lucas EK, Dougherty SE, McMeekin LJ, Reid CS, Dobrunz LE, West AB, Hablitz JJ, Cowell RM. J Neurosci. 2014 Oct 22;34(43):14375-87. doi: 10.1523/JNEUROSCI.1222-14.2014. PubMed
Dynamic partnership between TFIIH, PGC-1alpha and SIRT1 is impaired in trichothiodystrophy. Traboulsi H, Davoli S, Catez P, Egly JM, Compe E. PLoS Genet. 2014 Oct 23;10(10):e1004732. doi: 10.1371/journal.pgen.1004732. eCollection 2014 Oct. PubMed
CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1alpha. Gao J, Yan J, Xu M, Ren S, Xie W. Mol Endocrinol. 2015 Nov;29(11):1558-70. doi: 10.1210/me.2015-1145. Epub 2015 Sep 25. PubMed
The transcriptional coregulator PGC-1beta controls mitochondrial function and anti-oxidant defence in skeletal muscles. Gali Ramamoorthy T, Laverny G, Schlagowski AI, Zoll J, Messaddeq N, Bornert JM, Panza S, Ferry A, Geny B, Metzger D. Nat Commun. 2015 Dec 17;6:10210. doi: 10.1038/ncomms10210. PubMed
IGF-II-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in myoblast cells involves PI3K/Akt/FoxO1 signaling pathway. Mu X, Qi W, Liu Y, Zhou J, Li Y, Rong X, Lu L. Mol Cell Biochem. 2017 Aug;432(1-2):199-208. doi: 10.1007/s11010-017-3010-4. Epub 2017 Apr 3. PubMed
Activation of the ATF2/CREB-PGC-1alpha pathway by metformin leads to dopaminergic neuroprotection. Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH. Oncotarget. 2017 Jul 25;8(30):48603-48618. doi: 10.18632/oncotarget.18122. PubMed
NIK links inflammation to hepatic steatosis by suppressing PPARalpha in alcoholic liver disease. Li Y, Chen M, Zhou Y, Tang C, Zhang W, Zhong Y, Chen Y, Zhou H, Sheng L. Theranostics. 2020 Feb 18;10(8):3579-3593. doi: 10.7150/thno.40149. eCollection 2020. PubMed
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, Peralta R, Wang Y, Wang Y, DePeaux K, Poholek AC, Delgoffe GM. Nat Immunol. 2021 Feb;22(2):205-215. doi: 10.1038/s41590-020-00834-9. Epub 2021 Jan 4. PubMed
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, Lopez-Giraldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, Gonzalez Zapata S, Dann P, Brown SN, Hirabara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS. Nat Metab. 2021 Mar;3(3):378-393. doi: 10.1038/s42255-021-00359-x. Epub 2021 Mar 8. PubMed
RNA-bound PGC-1alpha controls gene expression in liquid-like nuclear condensates. Perez-Schindler J, Kohl B, Schneider-Heieck K, Leuchtmann AB, Henriquez-Olguin C, Adak V, Maier G, Delezie J, Sakoparnig T, Vargas-Fernandez E, Karrer-Cardel B, Ritz D, Schmidt A, Hondele M, Jensen TE, Hiller S, Handschin C. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105951118. doi: 10.1073/pnas.2105951118. PubMed
PGC1 alpha coactivates ERG fusion to drive antioxidant target genes under metabolic stress. Dhara A, Aier I, Paladhi A, Varadwaj PK, Hira SK, Sen N. Commun Biol. 2022 May 4;5(1):416. doi: 10.1038/s42003-022-03385-x. PubMed
Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1alpha Stability. Hou Y, Sun X, Gheinani PT, Guan X, Sharma S, Zhou Y, Jin C, Yang Z, Naren AP, Yin J, Denning TL, Gewirtz AT, Liu Y, Xie Z, Li C. Cell Mol Gastroenterol Hepatol. 2022;14(2):375-403. doi: 10.1016/j.jcmgh.2022.05.006. Epub 2022 May 25. PubMed

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