HDAC4 Flag Citations (32)

Originally described in: A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p.
Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E J Biol Chem. 1999 Apr 23. 274(17):11713-20. PubMed Journal

---

Articles Citing HDAC4 Flag

Articles
Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. Chen CH, Huang PH, Chu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q, Chen CS. J Biol Chem. 2011 Mar 25;286(12):9968-76. doi: 10.1074/jbc.M110.203240. Epub 2011 Jan 31. PubMed
Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. Hsu YF, Sheu JR, Lin CH, Yang DS, Hsiao G, Ou G, Chiu PT, Huang YH, Kuo WH, Hsu MJ. Biochim Biophys Acta. 2012 Feb;1820(2):104-15. doi: 10.1016/j.bbagen.2011.11.011. Epub 2011 Dec 1. PubMed
The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. Darlyuk-Saadon I, Weidenfeld-Baranboim K, Yokoyama KK, Hai T, Aronheim A. Biochim Biophys Acta. 2012 Nov-Dec;1819(11-12):1142-53. doi: 10.1016/j.bbagrm.2012.09.005. Epub 2012 Sep 16. PubMed
Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Isaacs JT, Antony L, Dalrymple SL, Brennen WN, Gerber S, Hammers H, Wissing M, Kachhap S, Luo J, Xing L, Bjork P, Olsson A, Bjork A, Leanderson T. Cancer Res. 2013 Feb 15;73(4):1386-99. doi: 10.1158/0008-5472.CAN-12-2730. Epub 2012 Nov 13. PubMed
Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. Chang HL, Chen CY, Hsu YF, Kuo WS, Ou G, Chiu PT, Huang YH, Hsu MJ. Biochim Biophys Acta. 2013 Aug;1830(8):4053-64. doi: 10.1016/j.bbagen.2013.04.011. Epub 2013 Apr 12. PubMed
Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1beta signaling in osteoarthritis fibroblast-like synoviocytes. Wang JH, Shih KS, Wu YW, Wang AW, Yang CR. Osteoarthritis Cartilage. 2013 Dec;21(12):1987-96. doi: 10.1016/j.joca.2013.09.008. Epub 2013 Oct 6. PubMed
Overexpression of the transcriptional repressor complex BCL-6/BCoR leads to nuclear aggregates distinct from classical aggresomes. Buchberger E, El Harchi M, Payrhuber D, Zommer A, Schauer D, Simonitsch-Klupp I, Bilban M, Brostjan C. PLoS One. 2013 Oct 11;8(10):e76845. doi: 10.1371/journal.pone.0076845. eCollection 2013. PubMed
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Duncan CE, An MC, Papanikolaou T, Rugani C, Vitelli C, Ellerby LM. Mol Neurodegener. 2013 Oct 27;8:42. doi: 10.1186/1750-1326-8-42. PubMed
The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Kritzer MD, Li J, Passariello CL, Gayanilo M, Thakur H, Dayan J, Dodge-Kafka K, Kapiloff MS. Circ Heart Fail. 2014 Jul;7(4):663-72. doi: 10.1161/CIRCHEARTFAILURE.114.001266. Epub 2014 May 8. PubMed
E2F1-mediated FOS induction in arsenic trioxide-induced cellular transformation: effects of global H3K9 hypoacetylation and promoter-specific hyperacetylation in vitro. Rahman S, Housein Z, Dabrowska A, Mayan MD, Boobis AR, Hajji N. Environ Health Perspect. 2015 May;123(5):484-92. doi: 10.1289/ehp.1408302. Epub 2015 Jan 9. PubMed
Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. Huang HL, Peng CY, Lai MJ, Chen CH, Lee HY, Wang JC, Liou JP, Pan SL, Teng CM. Oncotarget. 2015 Mar 10;6(7):4976-91. PubMed
AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1alpha and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Chen S, Yin C, Lao T, Liang D, He D, Wang C, Sang N. Cell Cycle. 2015 Aug 3;14(15):2520-36. doi: 10.1080/15384101.2015.1055426. Epub 2015 Jun 10. PubMed
Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor. Lee HA, Song MJ, Seok YM, Kang SH, Kim SY, Kim I. PLoS One. 2015 Aug 25;10(8):e0136801. doi: 10.1371/journal.pone.0136801. eCollection 2015. PubMed
The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. Huang YH, Huang SW, Hsu YF, Ou G, Huang WJ, Hsu MJ. Sci Rep. 2015 Oct 29;5:15900. doi: 10.1038/srep15900. PubMed
Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma. Chen MC, Huang HH, Lai CY, Lin YJ, Liou JP, Lai MJ, Li YH, Teng CM, Yang CR. Oncotarget. 2016 Jan 5;7(1):402-17. doi: 10.18632/oncotarget.6352. PubMed
Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade. Yen CS, Chen JC, Chang YF, Hsu YF, Chiu PT, Shiue C, Chuang YF, Ou G, Hsu MJ. Sci Rep. 2016 Apr 28;6:25082. doi: 10.1038/srep25082. PubMed
The LIM domain protein nTRIP6 acts as a co-repressor for the transcription factor MEF2C in myoblasts. Kemler D, Dahley O, Rosswag S, Litfin M, Kassel O. Sci Rep. 2016 Jun 13;6:27746. doi: 10.1038/srep27746. PubMed
Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6. Liu HM, Jiang F, Loo YM, Hsu S, Hsiang TY, Marcotrigiano J, Gale M Jr. EBioMedicine. 2016 Jul;9:195-206. doi: 10.1016/j.ebiom.2016.06.015. Epub 2016 Jun 11. PubMed
HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder. Trazzi S, Fuchs C, Viggiano R, De Franceschi M, Valli E, Jedynak P, Hansen FK, Perini G, Rimondini R, Kurz T, Bartesaghi R, Ciani E. Hum Mol Genet. 2016 Jul 27. pii: ddw231. PubMed
Novel role and regulation of HDAC4 in cocaine-related behaviors. Penrod RD, Carreira MB, Taniguchi M, Kumar J, Maddox SA, Cowan CW. Addict Biol. 2018 Mar;23(2):653-664. doi: 10.1111/adb.12522. Epub 2017 Jun 21. PubMed
WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via SHP-1-STAT3-survivin cascade. Chuang YF, Huang SW, Hsu YF, Yu MC, Ou G, Huang WJ, Hsu MJ. Br J Pharmacol. 2017 Jun 23. doi: 10.1111/bph.13929. PubMed
G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin. Wang YF, Zhang J, Su Y, Shen YY, Jiang DX, Hou YY, Geng MY, Ding J, Chen Y. Nat Commun. 2017 Aug 17;8(1):274. doi: 10.1038/s41467-017-00350-9. PubMed
Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome. Chandran JS, Sharp PS, Karyka E, Aves-Cruzeiro JMDC, Coldicott I, Castelli L, Hautbergue G, Collins MO, Azzouz M. Sci Rep. 2017 Nov 7;7(1):14766. doi: 10.1038/s41598-017-15255-2. PubMed
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity. Kalogeropulou AF, Zhao J, Bolliger MF, Memou A, Narasimha S, Molitor TP, Wilson WH, Rideout HJ, Nichols RJ. Biochem J. 2018 Apr 9;475(7):1271-1293. doi: 10.1042/BCJ20170699. PubMed
Bidirectional regulation of HDAC5 by mAKAPbeta signalosomes in cardiac myocytes. Dodge-Kafka KL, Gildart M, Li J, Thakur H, Kapiloff MS. J Mol Cell Cardiol. 2018 May;118:13-25. doi: 10.1016/j.yjmcc.2018.03.001. Epub 2018 Mar 6. PubMed
MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis. Brescia P, Schneider C, Holmes AB, Shen Q, Hussein S, Pasqualucci L, Basso K, Dalla-Favera R. Cancer Cell. 2018 Sep 10;34(3):453-465.e9. doi: 10.1016/j.ccell.2018.08.006. PubMed
Nucleoporin Nup155 is part of the p53 network in liver cancer. Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Bassler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S. Nat Commun. 2019 May 14;10(1):2147. doi: 10.1038/s41467-019-10133-z. PubMed
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Lu Y, Stuart JH, Talbot-Cooper C, Agrawal-Singh S, Huntly B, Smid AI, Snowden JS, Dupont L, Smith GL. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11997-12006. doi: 10.1073/pnas.1816399116. Epub 2019 May 24. PubMed
Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase 4 in macrophages. Kang H, Park YK, Lee JY. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jan;1866(1):158838. doi: 10.1016/j.bbalip.2020.158838. Epub 2020 Oct 13. PubMed
ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses. Bruce JW, Bracken M, Evans E, Sherer N, Ahlquist P. PLoS Pathog. 2021 Feb 26;17(2):e1009364. doi: 10.1371/journal.ppat.1009364. eCollection 2021 Feb. PubMed
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Elsasser SJ, Skodras AA, Gloeckner CJ, Buratti E, Neumann M, Kahle PJ. Nat Commun. 2022 Mar 9;13(1):1223. doi: 10.1038/s41467-022-28822-7. PubMed
Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning. Shi F, de Fatima Silva F, Liu D, Patel HU, Xu J, Zhang W, Turk C, Kruger M, Collins S. Mol Metab. 2023 Aug;74:101753. doi: 10.1016/j.molmet.2023.101753. Epub 2023 Jun 13. PubMed

If you have published an article using this material, please email us at to have your article added to this page.